Results 71 to 80 of about 36,822 (224)

Lens connexins α3Cx46 and α8Cx50 interact with zonula occludens protein-1 (ZO-1) [PDF]

, 2003
Connexin α1Cx43 has previously been shown to bind to the PDZ domain–containing protein ZO-1. The similarity of the carboxyl termini of this connexin and the lens fiber connexins α3Cx46 and α8Cx50 suggested that these connexins may also interact with ZO-1.
Baruch, Amos, Benedetti, E. Lucio, Dunia, Irene, Giepmans, Ben N.G., Kumar, Nalin M, Nielsen, Peter A, Shestopalov, Valery I   +6 more
core   +3 more sources

Zonula Occludens-1, Occludin, and E-cadherin Protein Expression in Biliary Tract Cancers

Pathology & Oncology Research, 2009
The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin.
Németh, Zsuzsanna, Szász, Attila Marcell, Somorácz, Áron, Tátrai, Péter, Németh, J., Győrffy, Hajnalka, Szijártó, Attila, Kupcsulik, Péter, Kiss, András, Schaff, Zsuzsa   +9 more
openaire   +3 more sources

INVESTİGATİON OF ZONULA OCCLUDENS-1 PROTEİN LEVEL İN RECTUM TİSSUE AFTER RADİOTHERAPY

International Journal of Research -GRANTHAALAYAH, 2020
The transmembrane protein zonula occludens of rectal tissue has function to prevents the spread of bacterial toxins into the intestinal mucosa and to systemic circulation. But radiotherapy causes ablation of crypt cell proliferation, mitotic catastrophe, and apoptosis leading to gastrointestinal mucositis.
Cengiz Kurtman, Esra Gümüştepe, Serdağ Demirören, Fatma Firat, Şaban Çakır Gökçe, Kemal Özbilgin   +5 more
openaire   +2 more sources

The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

Biomolecules, 2021
The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothelial ...
Randy E. Strauss, Louisa Mezache, Rengasayee Veeraraghavan, Robert G. Gourdie   +3 more
doaj   +1 more source

The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain [PDF]

Cellular and Molecular Life Sciences, 2009
Zonula occludens proteins (ZO) are postsynaptic density protein-95 discs large-zonula occludens (PDZ) domain-containing proteins that play a fundamental role in the assembly of tight junctions and establishment of cell polarity. Here, we show that the second PDZ domain of ZO-1 and ZO-2 binds phosphoinositides (PtdInsP) and we identified critical ...
Kris, Meerschaert, Moe Phyu, Tun, Eline, Remue, Ariane, De Ganck, Ciska, Boucherie, Berlinda, Vanloo, Gisèle, Degeest, Joël, Vandekerckhove, Pascale, Zimmermann, Nitin, Bhardwaj, Hui, Lu, Wonhwa, Cho, Jan, Gettemans   +12 more
openaire   +2 more sources

Protective effect of pericytes against vascular leakage in rats with hemorrhagic shock

Di-san junyi daxue xuebao, 2020
Objective To investigate the protective effect of pericytes (PCs) against vascular leakage in rats with hemorrhagic shock. Methods Sixty-four 12- to 24-week-old SD rats weighing 200~220 g were randomized equally into sham-operated group, hemorrhagic ...
HE Shuangshuang, ZHU Yu, ZHOU Henan, WANG Hongchen, LI Tao, LIU Liangming   +5 more
doaj   +1 more source

Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model

Burns & Trauma, 2019
Background The intestinal barrier integrity can be disrupted due to burn injury, which is responsible for local and systemic inflammatory responses. Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade ...
Yajun Song, Yang Li, Ya Xiao, Wengang Hu, Xu Wang, Pei Wang, Xiaorong Zhang, Jiacai Yang, Yong Huang, Weifeng He, Chibing Huang   +10 more
doaj   +1 more source

Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation [PDF]

, 2016
PURPOSE: We previously reported that applying toll-like receptor (TLR) ligands to an injured cornea induces corneal edema at 24 hours, which subsides by 1 week.
Larkin, DFP
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor [PDF]

, 2015
Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established.
Fujii, Yousuke, Morishima, Tsuneo, Nosaka, Nobuyuki, Saito, Yukie, Tsuge, Mitsuru, Tsukahara, Hirokazu, Yamada, Mutsuko, Yamashita, Nobuko, Yashiro, Masato   +8 more
core   +1 more source