Results 71 to 80 of about 31,557 (233)

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Prophylactic Effect of Rebamipide on Aspirin-Induced Gastric Lesions and Disruption of Tight Junctional Protein Zonula Occludens-1 Distribution

Journal of Pharmacological Sciences, 2008
Aspirin and nonsteroidal anti-inflammatory agents are known to induce gastroduodenal complications such as ulcer, bleeding, and dyspepsia. In this study, we examined the prophylactic effect of rebamipide, an anti-ulcer agent with free-radical scavenging ...
Takahiro Suzuki, Norimasa Yoshida, Nami Nakabe, Yutaka Isozaki, Hirokazu Kajikawa, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Hiroshi Ichikawa, Yuji Naito, Hirofumi Matsui, Toshikazu Yoshikawa   +11 more
doaj   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Tight junction protein ZO-1 in Kawasaki disease

BMC Pediatrics, 2021
Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo, Ho-Chang Kuo   +4 more
doaj   +1 more source

Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. [PDF]

, 2020
Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Choi, Julie, Ear, Jason, Ghassemian, Majid, Ghosh, Pradipta, Kufareva, Irina, Rajapakse, Navin, Saklecha, Anokhi   +6 more
core  

AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions [PDF]

, 2014
Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (C×36) is the most abundant isoform; however, the mechanisms underlying formation of C×36-containing electrical synapses ...
Abd-El-Barr, Anderson, Bloomfield, Chai, Christie, Ciolofan, Deans, Dedek, Demb, Dong, Dunn, Feigenspan, Flores, Güldenagel, Han, Helbig, Hilgen, Hormuzdi, Kolb, Kothmann, Kranz, Kumar, Li, Li, Li, Li, Li, Lin, Lynn, Maxeiner, Mills, Münch, Pan, Plantard, Rash, Rice, Schubert, Shelley, Strettoi, Söhl, Vaney, Veruki, Wachtmeister, Weymouth, Yu   +44 more
core   +6 more sources

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Foreword [PDF]

, 1941
The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common proteinprotein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found
Aarts, Bach, Bach, Bach, Bach, Bach, Bhattacharya, Chang, Charbonnier, Chen, Chi, Chi, Chi, Chi, Clarkson, Clarkson, Clausen, Cook, DeLano, Dhulesia, Doyle, El-Amraoui, Feng, Feng, Fodor, Fouassier, Fry, Fuentes, Fuentes, Fujii, Fujii, Fujii, Gallardo, Gerek, Gianni, Gianni, Goult, Grandy, Grembecka, Hajduk, Hammond, Haq, Haq, Harris, Hasselblatt, Hillier, Ho, Horovitz, Im, Ivarsson, Ivarsson, Jackson, Jemth, Joshi, Kachel, Kaneko, Karlsson, Kennedy, Kong, Law, LeBlanc, Lee, Lee, Lim, Liu, Liu, Lockless, Long, Mayasundari, Niu, Nomme, Nourry, Opazo, Pan, Pan, Patra, Peterson, Petit, Piserchio, Sainlos, Sakarya, Saro, Saupe, Shan, Shan, Shan, Skelton, Staneva, Stiffler, Subbaiah, Te Velthuis, Thorsen, Thorsen, Tochio, Udugamasooriya, van den Berk, von Ossowski, Walma, Wang, Wang, Wawrzyniak, Wells, Wiedemann, Wilken, Zhang, Zhang, Zhang, Zhang, Zimmermann   +108 more
core   +3 more sources

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Moderate Reduction in Dietary Net Energy Level Enhances Intestinal Health in Tunchang Pigs via Gut Microbiota Modulation

Animals
To investigate the effects of low net-energy (NE) diets on intestinal health in Tunchang pigs, 96 animals (25.40 ± 1.11 kg) were randomly assigned to four dietary treatment groups with NE levels of 9.82 (CG), 9.57 (EY1), 9.32 (EY2), and 9.07 (EY3) MJ/kg.
Xilong Yu, Hongzhi Wu, Haoliang Chai, Dexin Zhao, Weiqi Peng, Fengjie Ji, Lidong Zhang, Renlong Lv   +7 more
doaj   +1 more source