Results 131 to 140 of about 29,405 (257)

A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria

Fluids and Barriers of the CNS
Background Blood–brain barrier (BBB) disruption is a central feature of cerebral malaria (CM), a severe complication of Plasmodium falciparum (Pf) infections.
Adnan Gopinadhan, Jason M. Hughes, Andrea L. Conroy, Chandy C. John, Scott G. Canfield, Dibyadyuti Datta   +5 more
doaj   +1 more source

Looking at tricellulin expression in the brain [PDF]

, 2010
Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010It was recently reported the existence of a protein, called tricellulin (TRIC), concentrated at tricellular tight junctions (TJ) but also ...
Mariano, Cibelle Neiva Cavalcanti, 1984-
core  

Space biomedicine‐oriented bioink and biomimetic blood‒brain barrier

VIEW, EarlyView.
Bioinks and bioprinting play a pivotal role in the successful delivery of cell models and the fabrication of tissue models for space biomedicine research. This study investigated the effects of hypergravity and vibration on two‐dimensional adherent cells and three‐dimensional embedded cells and provided methods for storing hybrid bioink and high ...
Ranran Yan, Ge Gao, YuJuan Li, YuLin Deng   +3 more
wiley   +1 more source

Sunite sheep tail fat alleviates ulcerative colitis by regulating intestinal flora and metabolites to activate PPAR signaling pathway

Journal of Agriculture and Food Research
Ulcerative colitis (UC) is a topic of great concern, and there are no effective medications to treat it. Previous studies have shown that dietary adjustment may alleviate UC.
Jinhua Baoyindugurong, Pufang Liu, Chenchen Feng, Dan Chen, Lixing Wang, Jiletu Huge, Ronglun Hou, Yawen Li, Xinlei Yan   +8 more
doaj   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Abnormal development of gastrointestinal system of homozygous Foxp2(R552H)-mutated mice

Communications Biology
Forkhead box protein P2 (Foxp2) regulates the expression of genes related to organ morphogenesis. Homozygous Foxp2(R552H) knock-in (Foxp2 R552H/R552H) mice exhibit abnormal brain development, and die around the weaning period.
Eriko Fujita-Jimbo, Sachie Nakamura, Katsuko Sudo, Takashi Momoi   +3 more
doaj   +1 more source

High prevalence of loss of Claudin‐18 expression in invasive non‐mucinous lung adenocarcinoma: Potential diagnostic implications in routine practice

Histopathology, EarlyView.
Loss of Claudin‐18 (Cldn18) expression is a frequent and specific feature of non‐mucinous lung adenocarcinoma (NM‐LUAD). Cldn18 immunohistochemistry may serve as an ancillary tool for distinguishing malignant from non‐neoplastic alveolar epithelium, as well as for differentiating NM‐LUADs with mucin production from M‐LUADs, particularly in small or ...
Stefano Lucà, Marco Montella, Mario Fordellone, Riccardo Monti, Maria Giulia Disanto, Giuseppa Zannini, Marina Accardo, Maria Ali, Gaetano Di Guida, Carminia Maria Della Corte, Beatrice Leonardi, Severo Campione, Valerio Nardone, Floriana Morgillo, Alfonso Fiorelli, Luisella Righi, Mattia Barbareschi, Luka Brcic, Renato Franco   +18 more
wiley   +1 more source

Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy

Journal of Ophthalmology, 2015
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR.
Jianbo He, Hong Wang, Ying Liu, Wen Li, Dorothy Kim, Hu Huang   +5 more
doaj   +1 more source

Modulazione fisiologica della permeabilità intestinale e assorbimento di molecole idrofiliche [PDF]

, 1983
2009/2010La permeabilità intestinale è regolata dalle tight junctions (TJ) che costituiscono la barriera gastrointestinale e che sono soggette a regolazione fisiologica. Dati di letteratura dimostrano che digiuno e malnutrizione agiscono su tale barriera
De Leo, Luigina
core   +1 more source