Results 41 to 50 of about 29,405 (257)

Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation. [PDF]

, 2020
Background & aimsBiotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis.
Cahalan, Michael D, Hwang, Michael, Nakasaki, Manando, Sabui, Subrata, Said, Hamid M, Skupsky, Jonathan   +5 more
core  

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin [PDF]

, 2020
Streptococcus pneumoniae serotype 1 is the predominant cause of invasive pneumococcal disease in sub-Saharan Africa, but the mechanism behind its increased invasiveness is not well understood.
Baltazar, Murielle, Bricio-Moreno, Laura, Dowson, Christopher G., Everett, Dean B., Jacques, Laura C., Kadioglu, Aras, Khandaker, Shadia, Neill, Daniel R., Panagiotou, Stavros, Senghore, Madikay, Xu, Rong, Yang, Marie   +11 more
core   +4 more sources

Electrical synaptic transmission requires a postsynaptic scaffolding protein

eLife, 2021
Electrical synaptic transmission relies on neuronal gap junctions containing channels constructed by Connexins. While at chemical synapses neurotransmitter-gated ion channels are critically supported by scaffolding proteins, it is unknown if channels at ...
Abagael M Lasseigne, Fabio A Echeverry, Sundas Ijaz, Jennifer Carlisle Michel, E Anne Martin, Audrey J Marsh, Elisa Trujillo, Kurt C Marsden, Alberto E Pereda, Adam C Miller   +9 more
doaj   +1 more source

Structural Changes in the Carboxyl Terminus of the Gap Junction Protein Connexin40 Caused by the Interaction with c-Src and Zonula Occludens-1 [PDF]

Cell Communication & Adhesion, 2008
c-Src can disrupt the connexin 43 (Cx43) and zonula occludens-1 (ZO-1) interaction, leading to down-regulation of gap junction intercellular communication. Previously, the authors characterized the interaction of domains from these proteins with the carboxyl terminus of Cx43 (Cx43CT) and found that binding of the c-Src SH3 domain to Cx43CT disrupted ...
Denis, Bouvier, Fabien, Kieken, Admir, Kellezi, Paul L, Sorgen   +3 more
openaire   +2 more sources

Progesterone is neuroprotective by inhibiting cerebral edema after ischemia

Neural Regeneration Research, 2015
Ischemic edema can alter the structure and permeability of the blood-brain barrier. Recent studies have reported that progesterone reduces cerebral edema after cerebral ischemia.
Yuan-zheng Zhao, Min Zhang, Heng-fang Liu, Jian-ping Wang   +3 more
doaj   +1 more source

Supplementation of postbiotic RI11 improves antioxidant enzyme activity, upregulated gut barrier genes, and reduced cytokine, acute phase protein, and heat shock protein 70 gene expression levels in heat-stressed broilers

Poultry Science, 2021
The aim of this work was to evaluate the impacts of feeding different levels of postbiotic RI11 on antioxidant enzyme activity, physiological stress indicators, and cytokine and gut barrier gene expression in broilers under heat stress.
Ali Merzza Humam, Teck Chwen Loh, Hooi Ling Foo, Wan Ibrahim Izuddin, Idrus Zulkifli, Anjas Asmara Samsudin, Noordin Mohamed Mustapha   +6 more
doaj   +1 more source

Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. [PDF]

, 2006
OBJECTIVE: Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release
Carroccio A, Catassi C, CLEMENTE, MARIA GRAZIA, D'Agate C, Di Pierro M, Drago S, El Asmar R, Fasano A., Iacono G, Not T, Sapone A, Thakar M, Tripathi A, Zampini L   +13 more
core   +1 more source

Effect of Glucagon-like Peptide 2 on Tight Junction in Jejunal Epithelium of Weaned Pigs though MAPK Signaling Pathway [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
The glucagon-like peptide 2 (GLP-2) that is expressed in intestine epithelial cells of mammals, is important for intestinal barrier function and regulation of tight junction (TJ) proteins. However, there is little known about the intracellular mechanisms
Changsong Yu, Gang Jia, Yi Jiang, Qiuhong Deng, Zhengli Chen, Zhiwen Xu, Xiaolin Chen, Kangning Wang   +7 more
doaj   +1 more source

Effect of lonidamine derivatives on the inhibition of transformed cell area expansion

Biochemistry and Biophysics Reports, 2023
Expansion of transformed cell area is regulated by the surrounding nontransformed cells. Lonidamine (LND) was recently found to regulate transformed cell area expansion through suppressing the cell motility of nontransformed cells; however, the structure–
Megumi Aoyama, Taiki Homma, Ryohto Koharazawa, Yoshitomo Suhara, Kentaro Semba   +4 more
doaj   +1 more source

Foreword [PDF]

, 1941
The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common proteinprotein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found
Aarts, Bach, Bach, Bach, Bach, Bach, Bhattacharya, Chang, Charbonnier, Chen, Chi, Chi, Chi, Chi, Clarkson, Clarkson, Clausen, Cook, DeLano, Dhulesia, Doyle, El-Amraoui, Feng, Feng, Fodor, Fouassier, Fry, Fuentes, Fuentes, Fujii, Fujii, Fujii, Gallardo, Gerek, Gianni, Gianni, Goult, Grandy, Grembecka, Hajduk, Hammond, Haq, Haq, Harris, Hasselblatt, Hillier, Ho, Horovitz, Im, Ivarsson, Ivarsson, Jackson, Jemth, Joshi, Kachel, Kaneko, Karlsson, Kennedy, Kong, Law, LeBlanc, Lee, Lee, Lim, Liu, Liu, Lockless, Long, Mayasundari, Niu, Nomme, Nourry, Opazo, Pan, Pan, Patra, Peterson, Petit, Piserchio, Sainlos, Sakarya, Saro, Saupe, Shan, Shan, Shan, Skelton, Staneva, Stiffler, Subbaiah, Te Velthuis, Thorsen, Thorsen, Tochio, Udugamasooriya, van den Berk, von Ossowski, Walma, Wang, Wang, Wawrzyniak, Wells, Wiedemann, Wilken, Zhang, Zhang, Zhang, Zhang, Zimmermann   +108 more
core   +3 more sources