Results 21 to 30 of about 21,719 (253)

INVESTİGATİON OF ZONULA OCCLUDENS-1 PROTEİN LEVEL İN RECTUM TİSSUE AFTER RADİOTHERAPY

International Journal of Research -GRANTHAALAYAH, 2020
The transmembrane protein zonula occludens of rectal tissue has function to prevents the spread of bacterial toxins into the intestinal mucosa and to systemic circulation. But radiotherapy causes ablation of crypt cell proliferation, mitotic catastrophe, and apoptosis leading to gastrointestinal mucositis.
Cengiz Kurtman, Esra Gümüştepe, Serdağ Demirören, Fatma Firat, Şaban Çakır Gökçe, Kemal Özbilgin   +5 more
openaire   +2 more sources

Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome

Journal of Translational Medicine, 2023
Background Preclinical studies in acute respiratory distress syndrome (ARDS) have suggested that inhaled sevoflurane may have lung-protective effects and clinical trials are ongoing to assess its impact on major clinical outcomes in patients with ARDS ...
Ruoyang Zhai, Woodys Lenga Ma Bonda, Charlotte Leclaire, Cécile Saint-Béat, Camille Theilliere, Corinne Belville, Randy Coupet, Raiko Blondonnet, Damien Bouvier, Loic Blanchon, Vincent Sapin, Matthieu Jabaudon   +11 more
doaj   +1 more source

Localization and expression of zonula occludens-1 tight junction-associated protein in baboon (Papio anubis) corpora lutea [PDF]

Human Reproduction, 1996
The identification of the cell junction-forming proteins connexin-43, a gap junction protein and E-cadherin, which is a component of adherent junctions, in the corpus luteum of both humans and baboons suggests that cell-cell interactions and metabolic cooperation must occur in this tissue.
F S, Khan-Dawood, J, Yang, M Y, Dawood
openaire   +2 more sources

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background α Carboxyl terminus 1 (αCT1) is a 25–amino acid therapeutic peptide incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic wounds.
Jingbo Jiang, Daniel Hoagland, Joseph A. Palatinus, Huamei He, Jegan Iyyathurai, L. Jane Jourdan, Geert Bultynck, Zhen Wang, Zhiwei Zhang, Kevin Schey, Steven Poelzing, Francis X. McGowan, Robert G. Gourdie   +12 more
doaj   +1 more source

TAZ interacts with zonula occludens‐1 and ‐2 proteins in a PDZ‐1 dependent manner

FEBS Letters, 2010
MINT‐7994937: ZO‐2 (uniprotkb:Q95168) binds (MI:0407) to TAZ (uniprotkb:Q9EPK5) by pull down (MI:0096) MINT‐7994900, MINT‐7994835, MINT‐7994885: ZO‐1 (uniprotkb:Q07157) physically interacts (MI:0915) with TAZ (uniprotkb:Q9EPK5) by pull down (MI:0096) MINT‐7995020: ZO‐2 (uniprotkb:Q9UDY2) and TAZ (uniprotkb:Q9GZV5) colocalize (MI:0403) by fluorescence ...
Remue, Eline, Meerschaert, Kris, Oka, Tsutomu, Boucherie, Ciska, Vandekerckhove, Joël, Sudol, Marius, Gettemans, Jan   +6 more
openaire   +2 more sources

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density [PDF]

, 2003
Epithelial tight junctions regulate paracellular permeability, restrict apical/basolateral intramembrane diffusion of lipids, and have been proposed to participate in the control of epithelial cell proliferation and differentiation.
Balda, MS, Matter, K, Karl Matter, Garrett, MD, Michelle D. Garrett, Maria S. Balda   +5 more
core   +1 more source

Fuzi polysaccharides improve immunity in immunosuppressed mouse models by regulating gut microbiota composition

Heliyon, 2023
Rationale and objectives: Fuzi, the dried root of Aconitum carmichaelii Debx, is one of the widely used traditional Chinese medicines. Fuzi polysaccharides are considered the most bioactive compounds with immunomodulatory functions, however, the ...
Ran Tu, Cheng Zhou, Wenfeng Huang, Zhengping Feng, Qiufang Zhao, Xiaofei Shi, Langjun Cui, Keke Chen   +7 more
doaj   +1 more source

Structural Changes in the Carboxyl Terminus of the Gap Junction Protein Connexin40 Caused by the Interaction with c-Src and Zonula Occludens-1 [PDF]

Cell Communication & Adhesion, 2008
c-Src can disrupt the connexin 43 (Cx43) and zonula occludens-1 (ZO-1) interaction, leading to down-regulation of gap junction intercellular communication. Previously, the authors characterized the interaction of domains from these proteins with the carboxyl terminus of Cx43 (Cx43CT) and found that binding of the c-Src SH3 domain to Cx43CT disrupted ...
Denis, Bouvier, Fabien, Kieken, Admir, Kellezi, Paul L, Sorgen   +3 more
openaire   +2 more sources

Inhibition of MicroRNA‐155 Supports Endothelial Tight Junction Integrity Following Oxygen‐Glucose Deprivation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Brain microvascular endothelial cells form a highly selective blood brain barrier regulated by the endothelial tight junctions. Cerebral ischemia selectively targets tight junction protein complexes, which leads to significant damage to ...
Juan Carlos Pena‐Philippides, Amy Sabrina Gardiner, Ernesto Caballero‐Garrido, Rong Pan, Yiliang Zhu, Tamara Roitbak   +5 more
doaj   +1 more source