Results 91 to 100 of about 31,457 (207)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Convergence of Wnt signalling on the HNF4a-driven transcription in controlling liver zonation [PDF]

, 2009
BACKGROUND & AIMS: In each hepatocyte, the specific repertoire of gene expression is influenced by its exact location along the portocentrovenular axis of the hepatic lobule and provides a reason for the liver functions compartmentalization defined ...
Alonzi, T, Amicone, Laura, Cicchini, Carla, Colletti, M, Conigliaro, Alice, Pasquini, E, Santangelo, L, Tripodi, Marco   +7 more
core   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Archidendron clypearia extract: Modulating intestinal inflammation and enhancing disease resistance in aquacultured American bullfrogs (Aquarana catesbeiana)

Aquaculture Reports
Intestinal inflammation and bacterial infections challenges in the aquaculture of American bullfrogs (Aquarana catesbeiana), impacting their health and productivity.
Kesong Chen, Han Lin, Jingyang Sun, Hua Li, Jie Ma, Zhendong Qin, Biao Jiang, Wei Li, Qing Wang, Youlu Su, Li Lin, Chun Liu   +11 more
doaj   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Zonula occludens (ZO)‐1 is required for epithelial morphogenesis and lumen development

The FASEB Journal, 2013
Epithelial morphogenesis involves establishment of cell polarity and formation of the tight and adherens junctions between adjacent cells. However, contributions of tight junctions to epithelial morphogenesis remain poorly understood. Studies of epithelia lacking the scaffold‐like tight junction protein ZO‐1 in 2D culture have identified reduced ...
Matthew Odenwald, Nora E. Joseph, Alan S. Fanning, Jerrold R. Turner   +3 more
openaire   +1 more source

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]

, 2019
Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland, Fromm, Anja, Fromm, Michael, Gorkiewicz, Gregor, Hering, Nina A., Högenauer, Christoph, Schulzke, Jörg-Dieter, Troeger, Hanno, Zechner, Ellen   +8 more
core   +1 more source

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Lactiplantibacillus plantarum IS-10506 Enhances Tight Junction Integrity in Bronchial Epithelium: An Experimental Study

Indonesian Biomedical Journal
BACKGROUND: Airway epithelium constitutes the initial structural defense against inhaled allergens, with its integrity primarily maintained through the formation of tight junctions (TJ) consisting of claudins, occludins, and zonula occludens (ZO ...
Deasy Fetarayani, Gatot Soegiarto, Ingrid Suryanti Surono, Anang Endaryanto, Alpha Fardah Athiyyah, Yetti Hernaningsih, Dyah Fauziah, I Ketut Sudiana, Budi Utomo, Cita Rosita Sigit Prakoeswa   +9 more
doaj   +1 more source

Foreword [PDF]

, 1941
The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common proteinprotein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found
Aarts, Bach, Bach, Bach, Bach, Bach, Bhattacharya, Chang, Charbonnier, Chen, Chi, Chi, Chi, Chi, Clarkson, Clarkson, Clausen, Cook, DeLano, Dhulesia, Doyle, El-Amraoui, Feng, Feng, Fodor, Fouassier, Fry, Fuentes, Fuentes, Fujii, Fujii, Fujii, Gallardo, Gerek, Gianni, Gianni, Goult, Grandy, Grembecka, Hajduk, Hammond, Haq, Haq, Harris, Hasselblatt, Hillier, Ho, Horovitz, Im, Ivarsson, Ivarsson, Jackson, Jemth, Joshi, Kachel, Kaneko, Karlsson, Kennedy, Kong, Law, LeBlanc, Lee, Lee, Lim, Liu, Liu, Lockless, Long, Mayasundari, Niu, Nomme, Nourry, Opazo, Pan, Pan, Patra, Peterson, Petit, Piserchio, Sainlos, Sakarya, Saro, Saupe, Shan, Shan, Shan, Skelton, Staneva, Stiffler, Subbaiah, Te Velthuis, Thorsen, Thorsen, Tochio, Udugamasooriya, van den Berk, von Ossowski, Walma, Wang, Wang, Wawrzyniak, Wells, Wiedemann, Wilken, Zhang, Zhang, Zhang, Zhang, Zimmermann   +108 more
core   +3 more sources