Results 151 to 160 of about 31,558 (238)

Da Yuan Yin Regulates Gut Microbiota and Improves Intestinal Injury in Sepsis

open access: yesFood Science &Nutrition, Volume 14, Issue 4, April 2026.
Sepsis mouse model was induced by LPS to investigate the effect of Da Yuan Yin (DYY) in vivo. Hematoxylin–eosin staining showed that DYY could reduce intestinal injury caused by sepsis. In addition, DYY can also inhibit inflammation, apoptosis, and promote cell proliferation in sepsis, and promote the expression of tight junction proteins.
Li Wang   +4 more
wiley   +1 more source

Atractylodes Macrocephala Polysaccharides Ameliorate Diabetic Hepatorenal Injury and Remodel Gut Microbiota in Mice

open access: yesFood Science &Nutrition, Volume 14, Issue 4, April 2026.
Atractylodes macrocephala polysaccharides alleviate diabetic liver and kidney injury in HFD/STZ‐induced mice by improving gut microbiota composition, restoring intestinal barrier function, and partially correcting disturbed unsaturated fatty acid metabolism.
Jiali Wu   +12 more
wiley   +1 more source

Crocin Supplementation Mitigates DSS‐Induced Ulcerative Colitis by Promoting Autophagy and Modulating Gut Microbiota in Mice

open access: yesFood Science &Nutrition, Volume 14, Issue 4, April 2026.
Crocin enhanced intestinal barrier integrity and alleviated colonic inflammation in DSS‐induced UC mice. Crocin promoted autophagy by targeting the AMPK/mTOR pathway. Crocin reshaped gut microbiota composition of UC mice. ABSTRACT Crocin has been widely recognized for its anti‐inflammatory and antioxidant properties.
Jiaoyang Xu   +8 more
wiley   +1 more source

Anisakis simplex products impair intestinal epithelial barrier function and occludin and zonula occludens-1 localisation in differentiated Caco-2 cells. [PDF]

open access: yesPLoS Negl Trop Dis, 2020
Carballeda-Sangiao N   +6 more
europepmc   +1 more source

[Expression of Zonula Occludens-1 in Cerebral Cortex Following Traumatic Brain Injury].

open access: yesFa yi xue za zhi, 2015
To observe the time-course expression of zonula occludens-1 (ZO-1) in cerebral cortex after traumatic brain injury (TBI).The TBI model of mouse was established. The mice were divided in 1 h, 3 h, 6 h, 12 h, 24 h, 3 d, 7 d after TBI, sham and control groups.
Tao, Wang   +5 more
openaire   +1 more source

Therapeutic Galectin‐3 Apheresis Improves Sepsis Outcomes Through Coordinated Neutrophil Modulation and Endothelial Barrier Preservation: A Translational Study

open access: yesMedComm, Volume 7, Issue 4, April 2026.
Gal‐3 apheresis reduces neutrophil hyperactivation (CXCL2/CXCL8, MPO, NETs), preserves endothelial barrier function (tight junctions, vWF/VCAM‐1/ICAM‐1), and attenuates PI3K/AKT/HIF‐1α signaling. These coordinated effects significantly improve hemodynamics, reduce pulmonary edema (ELWI), lower vasopressor and fluid requirements, and increase survival ...
Zhongyi Sun   +7 more
wiley   +1 more source

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

open access: yesMedComm, Volume 7, Issue 4, April 2026.
This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He   +10 more
wiley   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy   +16 more
wiley   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

open access: yesThe FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto   +8 more
wiley   +1 more source

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