Results 51 to 60 of about 31,558 (238)

Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases. [PDF]

PLoS ONE, 2012
BACKGROUND: Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently available.
Ariadna Mendoza-Naranjo, Peter Cormie, Antonio E Serrano, Rebecca Hu, Shay O'Neill, Chiuhui Mary Wang, Christopher Thrasivoulou, Kieran T Power, Alexis White, Thomas Serena, Anthony R J Phillips, David L Becker   +11 more
doaj   +1 more source

The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

Biomolecules, 2021
The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothelial ...
Randy E. Strauss, Louisa Mezache, Rengasayee Veeraraghavan, Robert G. Gourdie   +3 more
doaj   +1 more source

Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. [PDF]

, 2006
OBJECTIVE: Little is known about the interaction of gliadin with intestinal epithelial cells and the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We investigated whether gliadin has any immediate effect on zonulin release
Carroccio A, Catassi C, CLEMENTE, MARIA GRAZIA, D'Agate C, Di Pierro M, Drago S, El Asmar R, Fasano A., Iacono G, Not T, Sapone A, Thakar M, Tripathi A, Zampini L   +13 more
core   +1 more source

Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor [PDF]

, 2015
Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established.
Fujii, Yousuke, Morishima, Tsuneo, Nosaka, Nobuyuki, Saito, Yukie, Tsuge, Mitsuru, Tsukahara, Hirokazu, Yamada, Mutsuko, Yamashita, Nobuko, Yashiro, Masato   +8 more
core   +1 more source

Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia

Molecular Biology of the Cell, 2012
The structure and function of both adherens (AJ) and tight (TJ) junctions are dependent on the cortical actin cytoskeleton. The zonula occludens (ZO)-1 and -2 proteins have context-dependent interactions with both junction types and bind directly to F-actin and other cytoskeletal proteins, suggesting ZO-1 and -2 might regulate cytoskeletal activity at ...
Fanning, Alan S., Van Itallie, Christina M., Anderson, James M.   +2 more
openaire   +2 more sources

Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model

Burns & Trauma, 2019
Background The intestinal barrier integrity can be disrupted due to burn injury, which is responsible for local and systemic inflammatory responses. Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade ...
Yajun Song, Yang Li, Ya Xiao, Wengang Hu, Xu Wang, Pei Wang, Xiaorong Zhang, Jiacai Yang, Yong Huang, Weifeng He, Chibing Huang   +10 more
doaj   +1 more source

Protective effect of pericytes against vascular leakage in rats with hemorrhagic shock

Di-san junyi daxue xuebao, 2020
Objective To investigate the protective effect of pericytes (PCs) against vascular leakage in rats with hemorrhagic shock. Methods Sixty-four 12- to 24-week-old SD rats weighing 200~220 g were randomized equally into sham-operated group, hemorrhagic ...
HE Shuangshuang, ZHU Yu, ZHOU Henan, WANG Hongchen, LI Tao, LIU Liangming   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation [PDF]

, 2016
PURPOSE: We previously reported that applying toll-like receptor (TLR) ligands to an injured cornea induces corneal edema at 24 hours, which subsides by 1 week.
Larkin, DFP
core   +1 more source

Two‐Photon Polymerized Microvascular Environments for Multicellular Modeling of the Blood–Brain Tumor Barrier

Advanced Materials Technologies, EarlyView.
Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin, Sayba Z. Chowdhury, Maurice de Wit, Rania Head, Kiki Bals, Erwin Brosens, Marvin M. van Luijn, Hayri E. Balcioglu, Angelo Accardo, Pim J. French   +9 more
wiley   +1 more source