Results 81 to 90 of about 31,457 (207)

Membrane-Type 1 Matrix Metalloproteinase Expression Is Regulated by Zonula Occludens-1 in Human Breast Cancer Cells [PDF]

Cancer Research, 2005
Abstract The acquisition of a migratory/invasive phenotype by tumor cells is characterized by the loss of cell-cell adhesion contacts and the expression of degradative properties. In this study, we examined the effect of the disorganization of occludin/zonula occludens (ZO)-1 tight junction (TJ) complexes on the expression of membrane ...
Polette, Myriam, Gilles, Christine, Nawrocki-Raby, Béatrice, Lohi, Jouko, Hunziker, Walter, Foidart, Jean-Michel, Birembaut, Philippe, L.   +6 more
openaire   +5 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several
Déborah Neyrinck-Leglantier, Julien Lesage, Julien Lesage, Silvia Blacher, Arnaud Bonnomet, Arnaud Bonnomet, Walter Hunziker, Walter Hunziker, Agnès Noël, Valérian Dormoy, Béatrice Nawrocki-Raby, Christine Gilles, Myriam Polette, Myriam Polette   +13 more
doaj   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer [PDF]

, 2016
Oral mucositis is one of the most common and debilitating side effects of chemotherapy treatment. Patients are often unable to eat and drink, which can lead to poor clinical outcomes and extensive resource utilisation.
Bowen, J., Gibson, R., Logan, R., Van Sebille, Y., Wardill, H.   +4 more
core   +1 more source

Regulation of CXCL8/IL-8 Expression by Zonula Occludens-1 in Human Breast Cancer Cells [PDF]

Molecular Cancer Research, 2012
Abstract Accumulating data now suggest that ZO-1, once delocalized from tight junctions, could be implicated in the regulation of tumor-promoting genes. Because of their major implication in different steps of tumor progression, we investigated here the influence of ZO-1 on chemokines expression in breast cancer cells.
Brysse, Anne, Mestdagt, Mélanie, Polette, Myriam, Luczka, E., Hunziker, W., Noël, Agnès, Birembaut, P., Foidart, Jean-Michel, Gilles, Christine   +8 more
openaire   +3 more sources

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Effect of oral administration of Limosilactobacillus reuteri on intestinal barrier function and mucosal immunity of suckling piglets

Italian Journal of Animal Science, 2022
The aim of present study was to evaluate the effect of Limosilactobacillus reuteri (L. reuteri) on the intestinal barrier function and mucosal immunity of piglets at different suckling phase.
Qi Wang, Jing Wang, Renli Qi, Xiaoyu Qiu, Qian Sun, Jinxiu Huang, Ruisheng Wang   +6 more
doaj   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse

Developmental Biology, 2008
It is unknown whether or not tight junction formation plays any role in morula to blastocyst transformation that is associated with development of polarized trophoblast cells and fluid accumulation. Tight junctions are a hallmark of polarized epithelial cells and zonula occludens-1 (ZO-1) is a known key regulator of tight junction formation.
Wang, Hehai, Ding, Tianbing, Brown, Naoko, Yamamoto, Yasutoshi, Prince, Lawrence S., Reese, Jeff, Paria, B.C.   +6 more
openaire   +2 more sources