Results 11 to 20 of about 82,705 (293)

Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro.
Xu-Yang Deng, Jun-Jie Ke, Ying-Ying Zheng, Dong-Li Li, Kun Zhang, Xi Zheng, Jing-Ying Wu, Zhuang Xiong, Pan-Pan Wu, Xue-Tao Xu   +9 more
doaj   +1 more source

Inhibition of Digestive Enzymes and Antioxidant Activity of Extracts from Fruits of Cornus alba, Cornus sanguinea subsp. hungarica and Cornus florida - A Comparative Study [PDF]

, 2020
The fruits of some Cornus species (dogwoods) are used in traditional medicine and considered potential anti-diabetic and hypolipemic agents. The aim of the study was to determine the ability of extracts from Cornus alba (CA), Cornus florida (CF), and ...
Buchholz, Tina, Czerwińska, Monika E., Melzig, Matthias F., Stanisławska, Iwona, Truba, Joanna, Walasek, Marta, Wieczorkowska, Wioleta, Woliński, Konrad   +7 more
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Expression ofAspergillus oryzaeα-amylase gene inSaccharomyces cerevisiae [PDF]

FEMS Microbiology Letters, 1993
Abstract A fragment containing the full length cDNA from Aspergillus oryzae α-amylase has been amplified by PCR using specific synthetic oligonucleotides. The amplified cDNA was designed to favour its expression in yeast by modifying its upstream untranslated region.
Francisca Randez-Gil, Pascual Sanz
openaire   +1 more source

Isolation and purification of α-amylase inhibitors and their in vitro and in vivo effects on Tribolium castaneum (Herbst) and Callosobruchus maculatus (F.)

Journal of Plant Protection Research, 2020
Plant derived α-amylase inhibitors are proteinaceous molecules that regulate the enzyme activity in plants and also protect plants from insect attack. In the current study, 28 accessions of 19 plant species were screened for their α-amylase inhibitory ...
Ashraf Oukasha Abd El-latif, Nesma Mohieldeen, Ahmed Mahmoud Ali Salman, Elena N. Elpidina   +3 more
doaj   +1 more source

Impact of calcium on salivary α-amylase activity, starch paste apparent viscosity and thickness perception [PDF]

, 2011
Thickness perception of starch-thickened products during eating has been linked to starch viscosity and salivary amylase activity. Calcium is an essential cofactor for α-amylase and there is anecdotal evidence that adding extra calcium affects ...
A Kumari, AAD Comrie, AC Alting, AD Nielsen, AL Ferry, ALS Ferry, Andrew J. Taylor, AR Nazmi, BL Vallee, Cecile Morris, CF Gonzalez, CI Heinzerling, D Suvd, DS Bush, E Bertoft, E Salvolini, G Muralikrishna, ID Evans, J Hsiu, J Kivela, J Lin, JGL Harrison, JW Woolnough, L Engelen, L Sewon, LS Collado, M Machius, M O’Mahony, M Tietz, MJ Larsen, RA Wijk de, RG Schipper, Susanne L. Fichtel, WM Edgar   +33 more
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Clitoria ternatea L. flower extract inhibits α-amylase during in vitro starch digestion [PDF]

, 2017
This study aimed to investigate the inhibitory effect of Clitoria ternatea flower against α-amylase during simulated in vitro wheat starch digestion. The dark-blue tropical flower is used as a food colorant but its ability to modulate starch digestion ...
Chu, Boon-Seang, Divers, Rachel, Lemos, M. Adilia, Tziboula-Clarke, Athina   +3 more
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Expression of theStreptomyces griseusα-amylase gene inEscherichia coli [PDF]

FEMS Microbiology Letters, 1994
The amy gene of Streptomyces griseus was not expressed in Escherichia coli cells due to the lack of recognition of the amy promoter by the E. coli RNA polymerase, as confirmed by using promoter-probe vectors. The expression of the amy gene in E. coli was detected only when the promoter-less gene was placed under the control of the lacZ promoter and was
T. Vigal, J.F. Martin, J.A. Gil
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Molecular, Biochemical, and Dietary Regulation Features of α-Amylase in a Carnivorous Crustacean, the Spiny Lobster Panulirus argus. [PDF]

PLoS ONE, 2016
Alpha-amylases are ubiquitously distributed throughout microbials, plants and animals. It is widely accepted that omnivorous crustaceans have higher α-amylase activity and number of isoforms than carnivorous, but contradictory results have been obtained ...
Leandro Rodríguez-Viera, Erick Perera, Juan Antonio Martos-Sitcha, Rolando Perdomo-Morales, Antonio Casuso, Vivian Montero-Alejo, Tsai García-Galano, Gonzalo Martínez-Rodríguez, Juan Miguel Mancera   +8 more
doaj   +1 more source

α-Amylase inhibitors : a review of raw material and isolated compounds from plant source [PDF]

, 2012
Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases ...
Batista, Pérola de Oliveira Magalhães Dias, Sales, Paloma Michelle de, Silveira, Dâmaris, Simeoni, Luiz Alberto, Souza, Paula Monteiro de   +4 more
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Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors

Molecules, 2023
Current antidiabetic drugs have severe side effects, which may be minimized by new selective molecules that strongly inhibit α-glucosidase and weakly inhibit α-amylase.
Dolores G. Aguila-Muñoz, Gabriel Vázquez-Lira, Erika Sarmiento-Tlale, María C. Cruz-López, Fabiola E. Jiménez-Montejo, Víctor E. López y López, Carlos H. Escalante, Dulce Andrade-Pavón, Omar Gómez-García, Joaquín Tamariz, Aarón Mendieta-Moctezuma   +10 more
doaj   +1 more source