Results 111 to 120 of about 925,689 (154)

Cyclization of the Analgesic α-Conotoxin Vc1.1 With a Non-Natural Linker: Effects on Structure, Stability, and Bioactivity. [PDF]

J Pept Sci
Zhang Y, Tae HS, Adams DJ, Durek T, Craik DJ.   +4 more
europepmc   +1 more source

α-Conotoxins ImI and ImII: similar α7 nicotinic receptor antagonists act at different sites

, 2003
journal articleA novel conotoxin, α-conotoxin ImII (α-CTx ImII), identified from Conus imperialis venom ducts, was chemically synthesized. A previously characterized C.
Olivera, Baldomero M.; McIntosh, J. Michael, Ellison, Michael   +1 more
core  

α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice. [PDF]

Mar Drugs
Xu W, Wang M, Li X, He R, Ding RB, Bao J, Zhangsun D, Luo S.   +7 more
europepmc   +1 more source

Molecular determinants of the selectivity and potency of α-conotoxin Vc1.1 for human nicotinic acetylcholine receptors. [PDF]

J Biol Chem
Tae HS, Hung A, Clark RJ, Adams DJ.
europepmc   +1 more source

Direct Heterologous Expression of Cyclic Conotoxin [G22N]Vc1.1 in Yeast

Backbone-cyclized conotoxin Vc1.1 is a potent GABAB receptor agonist and analgesic drug lead for treating neuropathic pain. Here, we describe two yeast-based strategies for the direct recombinant production of this cyclic, disulfide-rich peptide.
Kuok Yap, Thomas Durek, David J. Craik, Jing Xie, Conan K. Wang   +4 more
core   +1 more source

α-Conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors

, 2002
journal articleMany venomous organisms produce toxins that disrupt neuromuscular communication to paralyze their prey. One common class of such toxins comprises nicotinic acetylcholine receptor antagonists (nAChRs).
Dowell, Cheryl; Watkins, Maren; Garrett, James E., Olivera, Baldomero M.; McIntosh, J. Michael; Yoshikami, Doju   +1 more
core  

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus. [PDF]

Mar Drugs
Neves JLB, Urcino C, Chase K, Dowell C, Hone AJ, Morgenstern D, Chua VM, Ramiro IBL, Imperial JS, Leavitt LS, Phan J, Fisher FA, Watkins M, Raghuraman S, Tun JO, Ueberheide BM, McIntosh JM, Vasconcelos V, Olivera BM, Gajewiak J.   +19 more
europepmc   +1 more source

GABA_B Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell-Derived Sensory Neurons by Baclofen and α-Conotoxin Vc1.1. [PDF]

J Neurochem
St Clair-Glover M, Yousuf A, Kaul D, Dottori M, Adams DJ.   +4 more
europepmc   +1 more source

A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity

, 2002
α-Conotoxin AuIB and a disulfide bond variant of AuIB have been synthesized to determine the role of disulfide bond connectivity on structure and activity.
Paul F Alewood (20218596), Ron C Hogg (20218581), Paramjit S Bansal (20218617), Julie L Dutton (20218614), David Adams (19587271), David J Craik (9619016)   +5 more
core  

Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of <i>α7</i> Nicotinic Acetylcholine Receptor in the Rat Brain. [PDF]

Mar Drugs
Shan H, Wang N, Gao X, Wang Z, Yu J, Zhangsun D, Zhu X, Luo S.   +7 more
europepmc   +1 more source