Results 91 to 100 of about 925,689 (154)

Effects of C-Terminal Carboxylation on α-Conotoxin LsIA Interactions with Human α7 Nicotinic Acetylcholine Receptor: Molecular Simulation Studies

Marine Drugs, 2019
α-Conotoxins selectively bind to nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets due to their important role in signaling transmission in excitable cells. A previous experimental study has demonstrated that carboxylation of
Jierong Wen, Andrew Hung
doaj   +1 more source

NMR solution conformation of and antitoxic analogue of α-conotoxin GI: identification of a common nicotinic acetylcholine receptor α₁-subunit binding surface for small ligans and α-conotoxins

, 1999
The three-dimensional solution conformation of an 11-residue antitoxic analogue of α-conotoxin GI, des-Glu1-[Cys3Ala]-des-Cys13-conotoxin GI (CANPACGRHYS-NH2, designated 'GI-15' henceforth), has been determined using two-dimensional 1H NMR spectroscopy ...
K Hun Mok, Kyou Hoon Han
core   +1 more source

α-Conotoxin PIA Is Selective for α6 Subunit-Containing Nicotinic Acetylcholine Receptors

, 2003
Until now, there have been no antagonists to discriminate between heteromeric nicotinic acetylcholine receptors (nAChRs) containing the very closely related α6 and α3 subunits. nAChRs containing α3, α4, or α6 subunits in combination with β2, occasionally
Baldomero M. Olivera, Doju Yoshikami, Cheryl Dowell, Maren Watkins, Alexander Kuryatov, James E. Garrett, Sarah T. Staheli, Jon M. Lindstrom, J. Michael McIntosh   +8 more
core   +1 more source

Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA

Molecules, 2014
Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs). Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as ...
Yong Wu, Xiaosa Wu, Jinpeng Yu, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source

Optimizing the connectivity in disulfide-rich peptides: α-conotoxin SII as a case study

, 2005
We describe a strategy for the efficient, unambiguous assignment of disulfide connectivities in α-conotoxin SII, of which ∼30% of its mass is cysteine, as an example of a generalizable technique for investigation of cysteine-rich peptides.
Livett, Bruce G., Broxton, Natalie M., Moczydlowski, Edward G., Jones, Alun, Down, John G., Bingham, Jon-Paul   +5 more
core   +1 more source

Optimal Cleavage and Oxidative Folding of α-Conotoxin TxIB as a Therapeutic Candidate Peptide

Marine Drugs, 2013
Alpha6beta2 nicotinic acetylcholine receptors (nAChRs) are potential therapeutic targets for the treatment of several neuropsychiatric diseases, including addiction and Parkinson’s disease.
Dongting Zhangsun, Sulan Luo, Qianqian Wu, Qiuyuan Yang, Furong Zhu, Yong Wu, Xiaosa Wu   +6 more
doaj   +1 more source

Discovery of Novel Antinociceptive α‑Conotoxin Analogues from the Direct In Vivo Screening of a Synthetic Mixture-Based Combinatorial Library

, 2016
Marine cone snail venoms consist of large, naturally occurring combinatorial libraries of disulfide-constrained peptide neurotoxins known as conotoxins, which have profound potential in the development of analgesics.
Shainnel O. Eans (1375899), Elisa Mizrachi (1577218), Kate J. Reilley (1983916), Michelle R. Hoot (1983919), Reena Gyanda (1983907), Richard A. Houghten (381453), Christopher J. Armishaw (1983910), Jayati Banerjee (1983913), Michelle L. Ganno (1375911), Jay P. McLaughlin (1375902)   +9 more
core   +1 more source

Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor

, 2022
α-Conotoxins that target muscle nicotinic acetylcholine receptors (nAChRs) commonly fall into two structural classes, frameworks I and II containing two and three disulfide bonds, respectively.
Yanni KY Chin (20254584), Nikita Abraham (1639795), Paul F Alewood (20218596), Patrick Wilhelm (1649827), David A Eagles (20254587), Chun Yuen Chow (8148093), David J Adams (8273148), Richard J Lewis (20218593), Karen Luna-Ramirez (12328901), Han Shen Tae (20023188), Glenn F King (20254590), Zoltan Dekan (2161108)   +11 more
core   +1 more source

Research into the Bioengineering of a Novel α-Conotoxin from the Milked Venom of Conus obscurus. [PDF]

Int J Mol Sci, 2022
Wiere S, Sugai C, Espiritu MJ, Aurelio VP, Reyes CD, Yuzon N, Whittal RM, Tytgat J, Peigneur S, Bingham JP.   +9 more
europepmc   +1 more source

Solution Structure of α-Conotoxin ImI by ¹H Nuclear Magnetic Resonance^†

, 2016
α-Conotoxin ImI derives from the venom of Conus imperialis and is the first and only small-peptide ligand that selectively binds to the neuronal α7 homopentameric subtype of the nicotinic acetylcholine receptor (nAChR).
Paul F. Alewood (1520788), Norelle L. Daly (457317), John Gehrmann (3023667), David J. Craik (13753)   +3 more
core   +1 more source