Results 71 to 80 of about 925,689 (154)
, 1998 Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3β4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally ...
Siqin Luo +6 more
core +1 more source
The Potential Role of Calcium Channels in Pulmonary Hypertension
BioMed Research International, Volume 2026, Issue 1, 2026.Pulmonary hypertension (PH) is a severe cardiovascular syndrome characterized by progressively elevated pulmonary arterial pressure and driven pathologically by sustained vasoconstriction and irreversible vascular remodeling. Growing evidence underscores the central role of calcium ion (Ca2+) signaling networks in PH pathogenesis, which dynamically ...
Ping Wu +5 more
wiley +1 more source
, 2001 A high resolution structure of α-conotoxin EI has been determined by 1H NMR spectroscopy and molecular modeling. α-Conotoxin EI has the same disulfide framework as α4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the ...
Jae Eun Suk +5 more
core +1 more source
Neural Plasticity, Volume 2026, Issue 1, 2026.Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha +7 more
wiley +1 more source
α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR
, 2006 The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and the hair cells of the cochlea.
McIntosh, J. Michael +6 more
core +1 more source
MedComm, Volume 6, Issue 12, December 2025.Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li +13 more
wiley +1 more source
Enhancing Stability and Albumin Binding Efficiency of α‑Conotoxin GI through Fatty Acid Modification
α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Quankuo He (17398282) +8 more
core +1 more source
α-Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes
, 1997 Activation of presynaptic nicotinic acetylcholine receptors (nAChRs) can induce the release of neurotransmitters such as dopamine and norepinephrine in the CNS.
Jennifer M. Kulak +3 more
core +1 more source
, 2021 Conotoxins are marine peptide toxins from marine cone snails. The α-conotoxin RegIIA can selectively act on human (h) α3β4 nicotinic acetylcholine receptor (nAChR), and is an important lead for drug development.
Liang Xue (174224) +4 more
core +1 more source
N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum
npj Parkinson's DiseaseThe secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α ...
Emmanouela Leandrou +3 more
doaj +1 more source