Results 51 to 60 of about 925,689 (154)
Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha +4 more
wiley +1 more source
Protein Science, Volume 35, Issue 9, September 2026.Abstract Disulfide‐rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80‐residue proteins conserved across gastropods that form a long‐standing orphan family whose structure and biological roles have remained unknown.
Oleg Melnyk +13 more
wiley +1 more source
A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]
, 2005 The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
McIntosh, J. Michael +11 more
core +1 more source
Pharmacological Research, 2023 The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle- or neuronal-type, however, the latter has also been reported in non-neuronal cells.
Han-Shen Tae, David J. Adams
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms
Frontiers in Cellular Neuroscience, 2021 Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits.
Victor Tsetlin +11 more
doaj +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
A Structure‐Informed Atlas of Venom‐Derived Peptides Reveals the Organization of Chemical Space
Molecular Informatics, Volume 45, Issue 5, May 2026.A structure‐informed atlas integrating sequence and AlphaFold‐derived features across 3,423 venom peptides reveals that chemical space is organized by disulfide‐stabilized compactness and electrostatic–hydrophobic balance, with functional classes clearly separated and convergent design principles overriding taxonomic origin.
Thaís Caroline Gonçalves +2 more
wiley +1 more source
, 2016 The α-conotoxins are potent and selective antagonists of nicotinic acetylcholine receptors (nAChR). Exploitation of these and other peptides in research and clinical settings has been hampered by the lability of the disulfide bridges that are essential ...
Jayamini Illesinghe (2392780) +7 more
core +1 more source
Protein Science, Volume 35, Issue 5, May 2026.Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney +12 more
wiley +1 more source