Results 51 to 60 of about 8,475 (115)
Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
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Marine Drugs, 2021 α9-containing nicotinic acetylcholine receptors (nAChRs) have been shown to play critical roles in neuropathic pain. The α-conotoxin (α-CTx) RgIA and its analog RgIA4 were identified as the most selective inhibitor of α9α10 nAChR.
Si Pan +5 more
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The Potential Role of Calcium Channels in Pulmonary Hypertension
BioMed Research International, Volume 2026, Issue 1, 2026.Pulmonary hypertension (PH) is a severe cardiovascular syndrome characterized by progressively elevated pulmonary arterial pressure and driven pathologically by sustained vasoconstriction and irreversible vascular remodeling. Growing evidence underscores the central role of calcium ion (Ca2+) signaling networks in PH pathogenesis, which dynamically ...
Ping Wu +5 more
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Neural Plasticity, Volume 2026, Issue 1, 2026.Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Shaik Basha +7 more
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MedComm, Volume 6, Issue 12, December 2025.Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li +13 more
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The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
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European Journal of Neuroscience, Volume 62, Issue 11, December 2025.ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Maria Ciscato +2 more
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Cancer Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Mohammad Hossein Azadi +3 more
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N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum
npj Parkinson's DiseaseThe secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α ...
Emmanouela Leandrou +3 more
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Structural similarities reveal an expansive conotoxin family with a two‐finger toxin fold
Protein Science, Volume 34, Issue 11, November 2025.Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Muhammad Saad Khilji +11 more
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