Results 61 to 70 of about 925,689 (154)

Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models [PDF]

, 2021
Several Conus-derived venom peptides are promising lead compounds for the management of neuropathic pain, with α-conotoxins being of particular interest.
Adams, David J., Chhabra, Sandeep, Zhao, Fei Yue, Burnley, James V., Sadeghi, Mahsa, Gooding, Simon G., Norton, Raymond S., Belgi, Alessia, Elnahriry, Khaled A., Tae, Han Shen, Spanswick, David, Macraild, Christopher A., Wei, Haifeng, Robinson, Samuel D., Bartels, Peter, Robinson, Andrea J.   +15 more
core   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Nuclear magnetic resonance solution conformation of α-conotoxin AuIB, an α3β4 subtype-selective neuronal nicotinic acetylcholine receptor antagonist

, 2000
The neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of α and β subunits, α-Conotoxins are a homologous series of small peptides that antagonize these receptors.
K Hun Mok, Baldomero M Olivera, Kyou Hoon Han, Kyu Hwan Park, J Michael McIntosh, Jee Hyun Cho   +5 more
core   +1 more source

Nuclear magnetic resonance solution conformation of α-conotoxin AuIB, an α3ß4 subtype-selective neuronal nicotinic acetylcholine receptor antagonist [PDF]

, 2000
journal articleThe neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of α and ß subunits.
Cho, Jee-Hyun; Mok, K. Hun; Park, Kyu-Hwan; Han, Kyou-Hoon, Olivera, Baldomero M.; McIntosh, J. Michael   +1 more
core  

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors

, 2015
Covalently attached peptide dendrimers can enhance binding affinity and functional activity. Homogenous di- and tetravalent dendrimers incorporating the α7-nicotinic receptor blocker α-conotoxin ImI (α-ImI) with polyethylene glycol spacers were designed ...
Adams, David J., David J. Adams (119198), Alewood, Paul F., Jingjing Wan (1639792), Blessy Paul (1639783), Wan, Jingjing, Joshua Lawson (1639789), Abraham, Nikita, Lawson, Joshua, Vetter, Irina, Mobli, Mehdi, Paul, Blessy, Lewis, Richard J., Nikita Abraham (1639795), Paul F. Alewood (1520788), Richard J. Lewis (30801), Han-Shen Tae (1639798), Huang, Johnny X., Irina Vetter (394252), Matthew A. Cooper (216663), Johnny X. Huang (1639786), Mehdi Mobli (233174), Cooper, Matthew A., Tae, Han-Shen   +23 more
core   +1 more source

From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR

Marine Drugs, 2021
α9-containing nicotinic acetylcholine receptors (nAChRs) have been shown to play critical roles in neuropathic pain. The α-conotoxin (α-CTx) RgIA and its analog RgIA4 were identified as the most selective inhibitor of α9α10 nAChR.
Si Pan, Yingxu Fan, Xiaopeng Zhu, Yi Xue, Sulan Luo, Xinquan Wang   +5 more
doaj   +1 more source

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, Volume 604, Issue 7, Page 3094-3113, 1 April 2026.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Interactions between the presynaptically active neurotoxins α-latrotoxin and ω-conotoxin GVIA: studies on calcium fluxes and binding parameters in rat and chicken synaptosomes

, 1990
Possible interactions between α-latrotoxin, an activator of synaptosomal calcium uptake, and ω-conotoxin GVIA, an inhibitor of voltage-sensitive calcium channels of the N-type, were investigated in rat and chicken synaptosomal preparations.
H. W. Scheer
core   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source