Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB [PDF]
Marine Drugs, 2020 α-Conotoxin TxIB specifically blocked α6/α3β2β3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to α6/α3β2β3 nAChRs.
Xincan Li +5 more
doaj +2 more sources
α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal [PDF]
Frontiers in Pharmacology, 2022 Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Kailin Mao +8 more
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DSPE-PEG Modification of α-Conotoxin TxID [PDF]
Marine Drugs, 2019 In order to improve stability of a peptide marine drug lead, α-conotoxin TxID, we synthesized and modified TxID at the N-terminal with DSPE-PEG-NHS by a nucleophilic substitution reaction to prepare the DSPE-PEG-TxID for the first time. The reaction
Weinan Zhao +3 more
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A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity [PDF]
Frontiers in PharmacologyBackground and PurposeNicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-
Wen Wang +9 more
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Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugsα-Conotoxins are disulfide-rich peptides obtained from the venom of cone snails, which are considered potential molecular probes and drug leads for nAChR-related disorders.
Jinpeng Yu +8 more
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α-Conotoxin Peptidomimetics: Probing the Minimal Binding Motif for Effective Analgesia [PDF]
Toxins, 2020 Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets—nicotinic acetylcholine and γ-aminobutyric acid ...
Adam C. Kennedy +5 more
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Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations [PDF]
Marine Drugs, 2020 Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders.
Jierong Wen, David J. Adams, Andrew Hung
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α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice [PDF]
Marine Drugs, 2020 Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Xiaodan Li +6 more
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α-Conotoxin as Potential to α7-nAChR Recombinant Expressed in Escherichia coli [PDF]
Marine Drugs, 2020 α7 nicotinic acetylcholine receptors (nAChR) is an important nicotinic acetylcholine receptors subtype and closely associated with cognitive disorders, such as Alzheimer’s and schizophrenia disease.
Yanli Liu +5 more
doaj +2 more sources
Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors [PDF]
Marine Drugsα-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions.
Tianmiao Li +7 more
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