Results 21 to 30 of about 925,689 (154)

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology
Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission.
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
doaj   +2 more sources

α-Conotoxin as Potential to α7-nAChR Recombinant Expressed in Escherichia coli [PDF]

Marine Drugs, 2020
α7 nicotinic acetylcholine receptors (nAChR) is an important nicotinic acetylcholine receptors subtype and closely associated with cognitive disorders, such as Alzheimer’s and schizophrenia disease.
Yanli Liu, Yifeng Yin, Yunyang Song, Kang Wang, Fanghui Wu, Hui Jiang   +5 more
doaj   +2 more sources

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors [PDF]

Marine Drugs
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions.
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Rilei Yu   +7 more
doaj   +2 more sources

Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3 [PDF]

Marine Drugs, 2018
α-Conotoxins (α-CTxs) are small peptides composed of 11 to 20 amino acid residues with two disulfide bridges. Most of them potently and selectively target nicotinic acetylcholine receptor (nAChR) subtypes, and a few were found to inhibit the GABAB ...
Jinqin Chen, Li Liang, Huying Ning, Fengtao Cai, Zhuguo Liu, Longxiao Zhang, Liangyi Zhou, Qiuyun Dai   +7 more
doaj   +2 more sources

Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects [PDF]

Molecules, 2019
A lack of specificity is restricting the further application of conotoxin from Conus bullatus (BuIA). In this study, an analogue library of BuIA was established and virtual screening was used, which identified high α7 nicotinic acetylcholine ...
Chen Liu, Pengxiang Wu, He Zhu, Paolo Grieco, Ruihe Yu, Xinmei Gao, Guiyue Wu, Dong Wang, Hanmei Xu, Weiyan Qi   +9 more
doaj   +2 more sources

Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. [PDF]

PLoS Computational Biology, 2011
α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission.
Rilei Yu, David J Craik, Quentin Kaas
doaj   +1 more source

α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors

Marine Drugs, 2020
Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a
Alexey V. Osipov, Tatiana I. Terpinskaya, Tatsiana Yanchanka, Tatjana Balashevich, Maxim N. Zhmak, Victor I. Tsetlin, Yuri N. Utkin   +6 more
doaj   +1 more source

α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal

Frontiers in Pharmacology, 2022
Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Kailin Mao, Xiaodan Li, Zongde Chen, Xiaoqian Dong, Dongting Zhangsun, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo, Sulan Luo   +8 more
doaj   +1 more source

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity [PDF]

, 2007
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack ...
Sixma, Titia K., Alewood, Paul F., Buettner, Regina, van Elk, R, Smit, A.B., Sixma, T., Dutertre, S., Nicke, A, van Elk, R., Smit, A., Nicke, Annette, Alewood, P. F., Sixma, T.K., Kendel, Y., Smit, AB, Lewis, R. J., Hopping, G., Kendel, Y, van Elk, René, Büttner, Regina, Elk, René van, Ulens, C, Ulens, Chris, Buttner, R, Kendel, Yvonne, Sixma, TK, Fish, Alexander, Lewis, R.J., Schroeder, Christina, Lewis, Richard,, Smit, August,, Buttner, R., Elk, R. van, Alewood, P.F., Lewis, Richard J., Fish, A, Sixma, Titia,, Schroeder, C., Alewood, Paul,, Fish, A., Alewood, P., Dutertre, Sébastien, Smit, August B., Ulens, C., Hopping, Gene, Nicke, A., Lewis, R.   +46 more
core   +1 more source

Ion Channels as Marine Drug Targets [PDF]

, 2020
Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr.

core   +2 more sources