α-Conotoxin Peptidomimetics: Probing the Minimal Binding Motif for Effective Analgesia [PDF]
Toxins, 2020 Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets—nicotinic acetylcholine and γ-aminobutyric acid ...
Adam C. Kennedy +5 more
doaj +4 more sources
α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t [PDF]
Toxins, 2017 Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD) spectroscopy and mass spectrometry (MS) were used to assess the effect of each chemical ...
Matthew W. Turner +2 more
doaj +4 more sources
Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB [PDF]
Marine Drugs, 2020 α-Conotoxin TxIB specifically blocked α6/α3β2β3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to α6/α3β2β3 nAChRs.
Xincan Li +5 more
doaj +2 more sources
DSPE-PEG Modification of α-Conotoxin TxID [PDF]
Marine Drugs, 2019 In order to improve stability of a peptide marine drug lead, α-conotoxin TxID, we synthesized and modified TxID at the N-terminal with DSPE-PEG-NHS by a nucleophilic substitution reaction to prepare the DSPE-PEG-TxID for the first time. The reaction
Weinan Zhao +3 more
doaj +2 more sources
Molecular docking study on the α3β2 neuronal nicotinic acetylcholine receptor complexed with α-Conotoxin GIC [PDF]
BMB Reports, 2012 Nicotinic acetylcholine receptors (nAChRs) are a diverse familyof homo- or heteropentameric ligand-gated ion channels.Understanding the physiological role of each nAChR subtypeand the key residues responsible for normal and pathologicalstates is ...
Chewook Lee +3 more
doaj +3 more sources
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli
Marine Drugs, 2016 α-Conotoxin LvIA is derived from Conus lividus, native to Hainan, and is the most selective inhibitor of α3β2 nicotinic acetylcholine receptors (nAChRs) known to date.
Xiaopeng Zhu +6 more
doaj +2 more sources
Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugsα-Conotoxins are disulfide-rich peptides obtained from the venom of cone snails, which are considered potential molecular probes and drug leads for nAChR-related disorders.
Jinpeng Yu +8 more
doaj +2 more sources
A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity [PDF]
Frontiers in PharmacologyBackground and PurposeNicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-
Wen Wang +9 more
doaj +2 more sources
α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice [PDF]
Marine Drugs, 2020 Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom.
Xiaodan Li +6 more
doaj +2 more sources
Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations [PDF]
Marine Drugs, 2020 Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders.
Jierong Wen, David J. Adams, Andrew Hung
doaj +2 more sources