Results 31 to 40 of about 1,700,583 (126)
Characterisation of a Novel A-Superfamily Conotoxin
Biomedicines, 2020 Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine ...
David T. Wilson +6 more
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British Journal of Pharmacology, 2021 Activation of GIRK channels via G protein‐coupled GABAB receptors has been shown to attenuate nociceptive transmission. The analgesic α‐conotoxin Vc1.1 activates GABAB receptors resulting in inhibition of Cav2.2 and Cav2.3 channels in mammalian primary ...
Anuja R. Bony +3 more
semanticscholar +1 more source
A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect
Frontiers in Pharmacology, 2022 A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized.
Shuo Wang +16 more
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Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus
Scientific Reports, 2021 The venom duct origins of predatory and defensive venoms has not been studied for hook-and-line fish hunting cone snails despite the pharmacological importance of their venoms. To better understand the biochemistry and evolution of injected predatory and
S. W. A. Himaya +5 more
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Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA
Scientific Reports, 2021 α-Conotoxins are small disulfide-rich peptides targeting nicotinic acetylcholine receptors (nAChRs) characterised by a CICII-Xm-CIII-Xn-CIV framework that invariably adopt the native globular conformations which is typically most potent. α-Conotoxins are
Thao N. T. Ho +2 more
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Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors
Molecules, 2021 Acetylcholine was the first neurotransmitter described. The receptors targeted by acetylcholine are found within organisms spanning different phyla and position themselves as very attractive targets for predation, as well as for defense. Venoms of snakes
Ayaulym Bekbossynova +2 more
doaj +1 more source
Journal of Medicinal Chemistry, 2020 The affinity of α-conotoxins, a class of nicotinic acetylcholine receptor (nAChR) peptide inhibitors, can be enhanced by dendrimerization. It has been hypothesized that this improvement arose from simultaneous binding of the α-conotoxins to several ...
Jiazhen Liang +5 more
semanticscholar +1 more source
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. [PDF]
PLoS Computational Biology, 2011 α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission.
Rilei Yu, David J Craik, Quentin Kaas
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Toxins, 2010 α-Conotoxins are peptide neurotoxins isolated from venomous marine cone snails that are potent and selective antagonists for different subtypes of nicotinic acetylcholine receptors (nAChRs).
Christopher J. Armishaw
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Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj +1 more source