Results 61 to 70 of about 1,700,583 (126)
Toxins, 2015 The α9α10-nicotinic acetylcholine receptor (nAChR) has been implicated in pain and has been proposed to be a novel target for analgesics. However, the evidence to support the involvement of the α9α10-nAChR in pain is conflicted.
Sarasa A. Mohammadi +1 more
doaj +1 more source
Cancer Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Mohammad Hossein Azadi +3 more
wiley +1 more source
Frontiers in Pharmacology, 2019 The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in heteropentameric assemblies with α10. Accumulating data indicate the presence of three different binding sites in α9α10 nAChRs: the α9(+)/α9(−), the α9(+)/α10(−), and the α10(+)
Marios Zouridakis +9 more
doaj +1 more source
DiPTH‐Cystine and PTH‐Cysteine in Disulfide Bond Analysis Using Automated Edman Degradation
Journal of Peptide Science, Volume 31, Issue 10, October 2025.The mystery of PTH‐cysteine and diPTH‐cystine in the analysis of disulfide bonds is solved. Both derivatives were synthesized and applied to Edman sequencing. A time‐efficient combined workflow applying Edman and MS/MS sequencing for a comprehensive analysis of the complex disulfide connectivity in peptides and proteins was developed.
Toni Kühl +3 more
wiley +1 more source
α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t
Toxins, 2017 Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD) spectroscopy and mass spectrometry (MS) were used to assess the effect of each chemical ...
Matthew W. Turner +2 more
doaj +1 more source
The Journal of Physiology, Volume 603, Issue 20, Page 6445-6465, October 15, 2025.Abstract figure legend A summary of age‐related changes contributing to reduced neurotransmission in mouse neuromuscular junctions (NMJ). At 26 months, NMJs showed potentiation in short‐term plasticity compared to 4‐ or 30‐month‐old synapses, which is a proxy for reduced probability of release within individual AZs (dashed arrow). Compared to NMJs from
Yizhi Li +7 more
wiley +1 more source
Frontiers in Pharmacology, 2019 Venomous marine snails of the genus Conus employ small peptides to capture prey, mainly osteichthyes, mollusks, and worms. A subset of these peptides known as α-conotoxins, are antagonists of nicotinic acetylcholine receptors (nAChRs).
Veronika Grau +5 more
doaj +1 more source
British Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li +9 more
wiley +1 more source
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl +6 more
wiley +1 more source
Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3
Marine Drugs, 2018 α-Conotoxins (α-CTxs) are small peptides composed of 11 to 20 amino acid residues with two disulfide bridges. Most of them potently and selectively target nicotinic acetylcholine receptor (nAChR) subtypes, and a few were found to inhibit the GABAB ...
Jinqin Chen +7 more
doaj +1 more source