Results 121 to 130 of about 57,365 (244)

ADSC‐Derived CCL8 Regulates HIF‐1α Signaling and Promotes Colorectal Cancer Progression in a 3D Coculture Platform

Cancer Science, EarlyView.
Schematic illustration showing how CRC‐associated ADSC‐derived CCL8 promotes colorectal cancer cell migration through ERK/HIF‐1α signaling in a 3D coculture platform. ABSTRACT This study aimed to recapitulate adipose‐tumor interactions within the colorectal cancer (CRC) tumor microenvironment (TME) and to elucidate the role of adipose‐derived stem ...
Jeong‐Eun Yun, Yeseon Son, Jieun Seo, Ki Yong Hong, Junji Fukuda, Do‐Won Jeong, Jong‐Wan Park, Yang‐Sook Chun   +7 more
wiley   +1 more source

The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity. [PDF]

PLoS Biol, 2022
Meek RW, Brockerman J, Fordwour OB, Zandberg WF, Davies GJ, Vocadlo DJ.   +5 more
europepmc   +1 more source

Adipocyte‐Derived Palmitic Acid Promotes Breast Cancer Malignancy via ZDHHC15‐Mediated S‐Palmitoylation of PPARγ

Cancer Science, EarlyView.
Adipocyte‐derived palmitic acid induces ZDHHC15‐mediated PPARγ S‐palmitoylation at Cys159, triggering its proteasomal degradation and promoting breast cancer malignancy with rosiglitazone resistance. Inhibition of PPARγ S‐palmitoylation by 2‐bromopalmitate suppresses breast cancer progression and synergistically enhances rosiglitazone efficacy ...
Geon Ho Moon, Min Young Lee, Jiwon Koh, Ki Yong Hong, Junji Fukuda, Sung Joon Kim, Yang‐Sook Chun   +6 more
wiley   +1 more source

Involvement of α-galactosidase OmAGAL2 in planteose hydrolysis during seed germination of Orobanche minor. [PDF]

J Exp Bot, 2022
Okazawa A, Baba A, Okano H, Tokunaga T, Nakaue T, Ogawa T, Shimma S, Sugimoto Y, Ohta D.   +8 more
europepmc   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes

Current Research in Biotechnology
Curcumin, the major bioactive compound found in turmeric (Curcuma longa) is a subject of intensive research, due to its multiple bioactivities. Previous studies have investigated metabolic effects of curcumin in humans or established animal research ...
Maima Matin, Natalia Ksepka, Kamil Wysocki, Michel-Edwar Mickael, Alpana Pande, Jarosław Olav Horbańczuk, Artur Jóźwik, Olga Adamska, Artur Stolarczyk, Laszlo Barna Iantovics, Yordanka Ilieva, Pencho Penchev, Atanas G. Atanasov   +12 more
doaj   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Heterologous Expression of a Thermostable α-Galactosidase from Parageobacillus thermoglucosidasius Isolated from the Lignocellulolytic Microbial Consortium TMC7. [PDF]

J Microbiol Biotechnol, 2022
Wang Y, Wang C, Chen Y, Cui M, Wang Q, Guo P.   +5 more
europepmc   +1 more source

Junctional Adhesion Molecule‐A (JAM‐A) Associates With High‐Risk Disease in Multiple Myeloma Patients and a Structure‐Based Rationally‐Designed Peptide Inhibitor Attenuates Tumorigenic Features In Vitro and In Vivo

European Journal of Haematology, EarlyView.
ABSTRACT Multiple myeloma (MM) is an incurable malignancy of terminally‐differentiated plasma cells that represents a major clinical challenge despite unprecedented therapeutic advances, particularly for patients with cytogenetically‐defined high‐risk MM (HR‐MM).
Niamh McAuley, Roisin McAvera, Dimitri Bong, Lara Donnelly, Izabela Cymer, Marian Brennan, Joanna Fay, Lance Hudson, John Quinn, Siobhan V. Glavey, Ann M. Hopkins   +10 more
wiley   +1 more source

Improved methods for the detection of β-galactosidase activity in colonies ofEscherichia coliusing a new chromogenic substrate: VBzTM-gal (2-(2-(4-(β-d-galactopyranosyloxy)-3-methoxyphenyl)-vinyl)-3-methylbenzothiazolium toluene-4-sulphonate) [PDF]

FEMS Microbiology Letters, 1991
B.W. Bainbridge, N. Mathias, R.G. Price, A.C. Richardson, J. Sandhu, B.V. Smith   +5 more
openaire   +1 more source