Results 181 to 190 of about 57,365 (244)
British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Safety evaluation of the food enzyme α-galactosidase from the genetically modified <i>Saccharomyces cerevisiae</i> strain CBS 615.94. [PDF]
EFSA JEFSA Panel on Food Contact Materials +24 more
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.Magnesium (Mg2+) attenuates renal injury in ischemia–reperfusion and radiation‐induced kidney injury models in association with reduced DNA damage response markers, cellular senescence, inflammation, and fibrosis. Mg2+ treatment is associated with reduced H3K4me3 enrichment at the p16INK4a promoter, attenuation of senescence‐associated pathways, and ...
Makoto Matsubara +12 more
wiley +1 more source
Influence of diet nutrient density and a multicarbohydrase containing α-galactosidase on performance, carcass characteristics, breast myopathies, and nutrient utilization of broilers reared from 1 to 42 days of age. [PDF]
Poult SciGulizia JP +10 more
europepmc +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva +10 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni +12 more
wiley +1 more source
α-Galactosidase and Sucrose-Kinase Relationships in a Bi-functional AgaSK Enzyme Produced by the Human Gut Symbiont Ruminococcus gnavus E1. [PDF]
Front Microbiol, 2020 Lafond M +13 more
europepmc +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher +8 more
wiley +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, Volume 13, Issue 46, 17 August 2026.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen +18 more
wiley +1 more source