Results 61 to 70 of about 997,954 (175)

Effective α-glycosidase inhibitors based on polyphenolic benzothiazole heterocycles

α-Glycosidase inhibition is one of the main approaches to treat Diabetes mellitus. Polyphenolic moieties are known to be responsible for yielding exhibit potent α-glycosidase inhibitory effects.
SEYHAN, GÖKÇE, Sevimli, Esra, Köksoy, Baybars, BARUT, BURAK, AKKAYA, DİDEM, SARI, SUAT   +5 more
core   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

In vitro and in silico analysis for elucidation of α-amylase and α-glucosidase: Synthesis, structural confirmation and drug likeness of benzothiazole derived thiazole base bis-Schiff base derivatives

Results in Chemistry
In this study, we have synthesized S-substituted benzothiazole derived thiazole bearing bis-Schiff base derivatives (1–19) and characterized via different spectroscopic techniques including NMR and HR-EIMS and then screened against α-amylase and α ...
Shoaib Khan, Tayyiaba Iqbal, Mujaddad Ur Rehman, Rafaqat Hussain, Yousaf Khan, Hayat Ullah, Mohsin Ali, Amjad Hussain, Saleh Alfarraj, Sulaiman Ali Alharbi   +9 more
doaj   +1 more source

Surface charge alterations in urinary extracellular vesicles mirror diabetic kidney disease pathophysiology

The FEBS Journal, EarlyView.
This study reveals that changes in the electrical charge, that is zeta potential of large extracellular vesicles (uEVs) found in urine, can reflect disease progression from diabetes to kidney scarring (fibrosis). With further clinical development, measurement of uEVs charge could provide a simple, noninvasive way to monitor disease progression and help
Melanie Tepuš, Maria Pia Savoca, Mabrouka Maamra, Conor J. Meehan, Dimitrios S. Goumenos, Timothy Johnson, Elisabetta A. M. Verderio   +6 more
wiley   +1 more source

Towards Tuneable Retaining Glycosidase-Inhibiting Peptides by Mimicry of a Plant Flavonol Warhead [PDF]

, 2017
Retaining glycosidases are an important class of enzymes involved in glycan degradation. To study better the role of specific enzymes in deglycosylation processes, and thereby the importance of particular glycosylation patterns, a set of potent ...
Afd Chemical Biology and Drug Discovery, Yoshisada, Ryoji, Ryoji Yoshisada, Lieke van Gijzel, Seino A. K. Jongkees, Chemical Biology and Drug Discovery, van Gijzel, Lieke, Jongkees, Seino A K   +7 more
core   +1 more source

Biotransformation of monoterpenols upon pre‐treatment with oregano essential oil vapour alleviates downy mildew susceptibility in grapevine leaves

Plant Biology, EarlyView.
Pre‐treatment of grapevine plants with oregano essential oil vapour alleviates downy mildew susceptibility by accumulation of monoterpenol glycosides. Abstract Grapevine downy mildew, caused by the oomycete Plasmopara viticola, is a destructive disease that causes major economic losses as most elite grapevine cultivars are susceptible to this pathogen.
J. R. P. E. Mars, R. M. de Graaf, R. S. Jansen, S. Coolen, P. H. J. Kouwer, J. L. Peters, R. A. Anaia   +6 more
wiley   +1 more source

Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis

Shipin gongye ke-ji
Objective: To elucidate the main components and mechanism of adjuvant prevention of type 2 diabetes of Citrus peel. Methods: The inhibitory activity of Citrus peel of α-glycosidase was determined in vitro.
Yan ZHANG, Ping YAN, Hua ZHANG, Han ZHANG, Mengdi ZHENG, Xiyan CHAI   +5 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Functionally substituted derivatives of novel thiourea and phenylthiourea as potent aldose reductase, α-amylase, and α-glycosidase inhibitors: in vitro and in silico studies

Phenylthiourea was synthesized for the first time with a yield of 75–80% based on thiourea, in the presence of various catalysts, and optimal conditions were identified for some reactions.
Sujayev, Afsun, Taslimi, Parham, Özçelik, Burak, Alwasel, Saleh H., Akkuş, Musa, GÜLÇİN, İlhami, Kılınç, Namık, Farzaliyev, Vagif, Sadeghian, Nastaran, Kilinc, Namik   +9 more
core   +1 more source

Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity

Synthetic and Systems Biotechnology
Acarbose is a potent glycosidase inhibitor widely used in the clinical treatment of type 2 diabetes mellitus (T2DM). Various acarbose analogs have been identified while exploring compounds with improved pharmacological properties. In this study, we found
Xin Zhang, Qungang Huang, Ziyue Guo, Feifei Cai, Qianjin Kang, Linquan Bai   +5 more
doaj   +1 more source