Results 41 to 50 of about 997,954 (175)

Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene–Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies

Pharmaceuticals
Background: Type 2 diabetes has become a significant global health challenge. Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a single medication ...
Osama Alharbi, Wael H. Alsaedi, Mosa Alsehli, Saif H. Althagafi, Hussam Y. Alharbi, Yazeed M. Asiri, Ramith Ramu, Mohammed Al-Ghorbani   +7 more
doaj   +1 more source

Biochemical Studies and Production Optimization of β‐Glucosidase From Microcystis aeruginosa CACIAM 03 Using Organic Waste

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Global warming and industrial pollutants pose significant threats to environmental sustainability. In response, enzymes have emerged as promising tools for mitigating pollution. Enzymatic hydrolysis is considered environmentally sustainable due to its biological nature.
Gustavo Marques Serra, Matheus Silva da Fonseca Diniz, Evonnildo Costa Gonçalves, Agenor Valadares Santos, Luciana Pereira Xavier   +4 more
wiley   +1 more source

Batch‐to‐Batch Optimization of pH Shifts in CHO Bioreactor Operations

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Culture pH is an important operating parameter in CHO cell cultures producing mAb since it directly affects growth and specific productivity. Mathematical models can be used to optimize the magnitude and timing of pH shifts provided that they are robust to model errors.
Ali Ghodba, Zahra Negahban, Anne Richelle, Chris McCready, Valerie Ward, Luis Ricardez‐Sandoval, Hector Budman   +6 more
wiley   +1 more source

Sulfonamide chalcone as a new class of α-glucosidase inhibitors

, 2005
Chalcones 1-20, a new class of glycosidase inhibitors, were synthesized, and their glycosidase inhibitory activities were investigated. Non-aminochalcones 1-12 had no inhibitory activity, however, aminochalcones 13-20 had strong glycosidase (α ...
M S Yang, M J Curtis-Long, K H Park, J E Kang, Hyun Sun Lee, Hyung Won Ryu, W D Seo, J H Kim   +7 more
core   +1 more source

Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil

Cumhuriyet Science Journal, 2021
The current research aimed to determine and report in vitro antioxidant, antimicrobial, antibiofilm, cytotoxic, anti-cholinesterase, and anti-diabetic properties and the stability of the major component of basic oil of Thymbra spicata var.
Faik Gökalp, Nuraniye Eruygur, Özge Çevik, Parham Taslimi, İlhami Gülçin, Ümit Muhammet Koçyiğit, Mehmet Ataş   +6 more
doaj   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Fluorinated Iminosugar Glycomimetics: Synthesis and Activity as GCase Ligands

European Journal of Organic Chemistry, EarlyView.
DAST‐mediated deoxyfluorination of suitably functionalized piperidines provided regio‐ and stereoselective access to fluorinated piperidine and pyrrolidine glycomimetics, the latter arising from an unusual ring‐contraction process. Fluorination generally enhanced β‐glucocerebrosidase (GCase) inhibitory potency, but lost PC activity toward L444P/L444P ...
Francesca Mangiavacchi, Alessio Morano, Cosimo Margheri, Cristina Faggi, Amelia Morrone, Camilla Matassini, Francesca Clemente, Andrea Goti, Martina Cacciarini, Francesca Cardona   +9 more
wiley   +1 more source

Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hyperglycemia, glucose fluctuations, and thyroid dysfunction contribute to the progression of diabetic nephropathy. This study aimed to investigate the associations of glycemia, glucose variability, and thyroid hormones with albuminuria in patients with type 2 diabetes mellitus (T2DM). In total, 451 T2DM patients were included.
Na Luo, Shang‐Yong Feng, Hui Chen, Dun‐Min She, Yan Liu, Ying Li, Cai‐Feng Yan, Zhen‐Wen Zhang, Jing Chen, Xiao‐Li Cai, Gao‐Yu Zhao, Hui Yu, Yan Wang   +12 more
wiley   +1 more source

Antidiabetic properties of dietary phenolic compounds: Inhibition effects on α‐amylase, aldose reductase, and α‐glycosidase [PDF]

, 2019
Aldose reductase (AR), alpha-amylase, and alpha-glycosidase are vital enzymes to prevent diabetic complications. Here, AR was purified from sheep kidney using elementary methods with 111.11-purification fold and with 0.85% purification yield.
Yeliz Demir, Demir, Yeliz, Taslimi, Parham, DURMAZ, LOKMAN, İlhami Gulçin, Lokman Durmaz, Parham Taslimi, GÜLÇİN, İlhami   +7 more
core   +1 more source

Standardization of extract of Leucaena leucocephala (lmk) De Wit seeds by α-glucosidase inhibitor [PDF]

, 2010
Extracts of Leucaena leucocephala (lmk) De Wit seeds were collected from different areas in Java; they include Jakarta, Cengkareng, Bogor and Bandung.
Syamsudin
core   +1 more source