Results 31 to 40 of about 997,954 (175)

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor [PDF]

, 2017
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Breen, I.Z., Ferraz, Maria J., Kuo, C.L., Van Der Marel, Gijsbert A., Aerts, J.M.F.G., Carme Rovira, Codee, J.D.C., Codée, Jeroen D.C., Wu, Liang, Johannes M. F. G. Aerts, Chi-Lin Kuo, Imogen Z. Breen, Davies, Gideon J., Marta Artola, Maria J. Ferraz, Raich, L., Marel, G.A. van der, Rovira, C., Overkleeft, H.S., Jeroen D. C. Codée, Gideon J. Davies, Davies, G.J., Raich, Lluís, Rovira, Carme, Liang Wu, Artola Perez de Azanza, M.E., Breen, Imogen Z., Gijsbert A. van der Marel, Wu, L., Offen, W.A., Overkleeft, Herman S., Artola, Marta, Guimaraes Da Lomba Ferraz, M.J., Aerts, Johannes M.F.G., Herman S. Overkleeft, Kuo, Chi Lin, Offen, Wendy A., Lluís Raich, Wendy A. Offen   +38 more
core   +1 more source

Chemical composition and physiological bioactivities of Stiefia multicaulis (Vahl) Soják Vahl grown in Palestine [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية
Background: Herbal products encompass a wide range of natural substances that show great potential as therapeutic materials. Consequently, there has been a substantial investigation into the therapeutic potential of numerous plant species in recent times.
Belal M. Rahhal
doaj   +1 more source

Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by LC-MS/MS

Life, 2023
Zivzik pomegranate (Punica granatum) has recently sparked considerable interest due to its nutritional and antioxidant properties. To evaluate the antioxidant capacities of P.
Hasan Karagecili, Ebubekir İzol, Ekrem Kirecci, İlhami Gulcin   +3 more
doaj   +1 more source

Novel coumarin-chalcone derivatives: Synthesis, characterization, antioxidant, cyclic voltammetry, molecular modelling and biological evaluation studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors

, 2023
In this study, a total of 12 coumarin-chalcone derivatives, 6 of which are original were synthesized. The structures of the newly synthesized compounds were elucidated by 1 H NMR, 13C NMR, IR, and elemental analysis methods (7g-7l).
Eda Mehtap Özden, İlhami Gülçin, Özden, Eda Mehtap, Erol Erçağ, Gülçin, İlhami, Hülya Çelik Onar, Hava Dudu Taslak, ÇELİK ONAR, HÜLYA, Onar, Hülya Çelik, Erçağ, Erol, Taslak, Hava Dudu, Ece, Abdulilah, Abdulilah Ece   +12 more
core   +1 more source

Activity-Based Protein Profiling for the Identification of Novel Carbohydrate-Active Enzymes Involved in Xylan Degradation in the Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1E

Frontiers in Microbiology, 2022
Activity-based protein profiling (ABPP) has so far scarcely been applied in Archaea in general and, especially, in extremophilic organisms. We herein isolated a novel Thermococcus strain designated sp.
Thomas Klaus, Sabrina Ninck, Andreas Albersmeier, Tobias Busche, Daniel Wibberg, Jianbing Jiang, Alexander G. Elcheninov, Kseniya S. Zayulina, Farnusch Kaschani, Christopher Bräsen, Herman S. Overkleeft, Jörn Kalinowski, Ilya V. Kublanov, Markus Kaiser, Bettina Siebers   +14 more
doaj   +1 more source

Synthesis of α-glycosidase hybrid nano-flowers and their application for enriching and screening α-glycosidase inhibitors

, 2018
To rapidly and accurately screen compounds present in traditional Chinese herbal medicines for α-glycosidase inhibitors, we synthesized a novel nano-affinity material to enable the targeted screening of α-glycosidase inhibitors.
Yuanyuan Zhang, Xiao-Ying Yin, Xi Wan, Jieming Liu, Shuting Gao, Weiting Liu, Han Wang, Kang Qian, Qing-Shan Liu   +8 more
core   +1 more source

Additional file 1 of Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling

, 2022
Additional file 1: Fig.S1. A PCR amplification of α-L-rhamnosidase gene from 11 positive clones (N1, N4, N5, N6, N8, N10, N12, N13,N14, N24 and N28).
Zijie Gong (14110736), Bo Yu (241082), Shiyu Luo (502460), Yuhan Ding (11718896), Ting Nie (148982)   +4 more
core   +1 more source

Antioxidant, antidiabetic, antiglaucoma, and anticholinergic effects of Tayfi grape (Vitis vinifera): A phytochemical screening by LC-MS/MS analysis

Open Chemistry, 2023
Grapes (Vitis vinifera), grape extracts, and grape products are known to possess beneficial effects. Antioxidant activity and enzyme inhibition activities of Tayfi grape (Vitis vinifera) extracts were studied and compared to standards. The IC50 values of
Karageçili Hasan, İzol Ebubekir, Kireçci Ekrem, Gülçin İlhami   +3 more
doaj   +1 more source

Potential antioxidant, anticholinergic, antidiabetic and antiglaucoma activities and molecular docking of spiraeoside as a secondary metabolite of onion (Allium cepa)

Saudi Pharmaceutical Journal, 2023
Onion contains many dietary and bioactive components including phenolics and flavonoids. Spiraeoside (quercetin-4-O-β-D-glucoside) is one of the most putative flavonoids in onion.
Lokman Durmaz, Hatice Kiziltas, Hasan Karagecili, Saleh Alwasel, İlhami Gulcin   +4 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source