Results 71 to 80 of about 12,529 (184)

The scale matters: A review on stimuli‐responsive microrobots categorized by scale for biomedical applications

Responsive Materials, EarlyView.
We systematically summarize how each scale dictates fundamental choices in design feature, manufacturing technology, driving mechanism, and control strategy, which are inherently governed by scale‐dominated physical principles. Furthermore, the application of scale‐determined operation modes of microrobots across different stages of medical ...
Hang Yin, Yujing Li, Guanghao Wu, Yubing Guo   +3 more
wiley   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, EarlyView.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies

Journal of Enzyme Inhibition and Medicinal Chemistry
We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase ...
Zorana Ferjancic, Filip Bihelovic, Bojan Vulovic, Radomir Matovic, Milena Trmcic, Aleksandar Jankovic, Milos Pavlovic, Filip Djurkovic, Radivoje Prodanovic, Aleksandra Djurdjevic Djelmas, Nevena Kalicanin, Mario Zlatovic, Dusan Sladic, Thomas Vallet, Marco Vignuzzi, Radomir N. Saicic   +15 more
doaj   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis

Shipin gongye ke-ji
Objective: To elucidate the main components and mechanism of adjuvant prevention of type 2 diabetes of Citrus peel. Methods: The inhibitory activity of Citrus peel of α-glycosidase was determined in vitro.
Yan ZHANG, Ping YAN, Hua ZHANG, Han ZHANG, Mengdi ZHENG, Xiyan CHAI   +5 more
doaj   +1 more source

Actividad antioxidante e inhibidora de a-glucosidasa y a-amilasa de tres variedades de cebolla (Allium cepa L.) [PDF]

, 2014
La cebolla (Allium cepa L.) ha sido cultivada durante miles de años y es utilizada como un componente importante en la dieta del ser humano. Estudios recientes sugieren que su consumo puede reducir o prevenir problemas de salud como asma, enfermedades ...
AGUILAR CISNEROS, LUISA, AGUILAR CISNEROS, LUISA, DUBLAN GARCIA, OCTAVIO, DUBLAN GARCIA, OCTAVIO, LOPEZ MARTINEZ, LETICIA XOCHITL, LOPEZ MARTINEZ, LETICIA XOCHITL   +5 more
core  

Evaluation of In Vitro Antioxidant, Anti-Obesity, and Anti-Diabetic Activities of [PDF]

, 2023
Opuntia ficus cladodes (OFC) are considered one of the wastes that result from opuntia cultivation, and their disposal by traditional methods results in many environmental problems. Therefore, this study was conducted with two aims.
Abdelrhman, Wesam Mohammed, Abdulmaguid, Nabila Yahia Mahmoud, Amin, Hesham F, Bahnasy, Rasha M, El-Hassanin, Marwa Fawzy, El-Wakeil, Nora Hamdy Mouhamed, Elashry, Arwa Mohamed Mohamed Mahmoud, Elgendy, Manal Salah Abbas, Elsebaie, Essam Mohamed, Khalil, Azhar Mostafa Mohamed, Mohamed, Alaa S   +10 more
core   +1 more source

Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes

The FEBS Journal, EarlyView.
Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni, Gabriel Oanca, Marco Orlando, Marina Lotti, Johan Åqvist, Marco Mangiagalli   +5 more
wiley   +1 more source

Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity

Synthetic and Systems Biotechnology
Acarbose is a potent glycosidase inhibitor widely used in the clinical treatment of type 2 diabetes mellitus (T2DM). Various acarbose analogs have been identified while exploring compounds with improved pharmacological properties. In this study, we found
Xin Zhang, Qungang Huang, Ziyue Guo, Feifei Cai, Qianjin Kang, Linquan Bai   +5 more
doaj   +1 more source

Three Closely Related Spodoptera Species Similarly Affect Gene Expression and Phytohormone Levels but Differentially Induce Volatile Emissions in Maize

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants can perceive specific elicitors in the oral secretions (OS) of herbivorous insects and respond by increasing their defences. Whether plants can discriminate among similar herbivorous insect species and differentially modulate their defence responses against them is largely unknown.
Wenfeng Ye, Sara Leite Dias, Marine Mamin, Carla C. M. Arce, Ted C. J. Turlings   +4 more
wiley   +1 more source