Results 31 to 40 of about 21,573 (205)

Effects of R-Alpha Lipoic Acid on HbA1c, Lipids and Blood Pressure in Type-2 Diabetics: A Preliminary Study [PDF]

, 2009
R-alpha lipoic acid (R-ALA) supplementation improves blood glucose in diabetic animals, but there have been no long-term clinical trials in humans testing its use for glucose control (HbA1c).
Hoffman, Elisa, Lukaszuk, Judith, Prawitz, Aimee D., Schultz, Theresa M.   +3 more
core   +2 more sources

Domino Polymerization for the Synthesis of Reductively Degradable Poly(disulfide)s With Arbitrary Side‐Chain Structures

Angewandte Chemie, EarlyView.
We developed a novel domino polymerization to synthesize reductively degradable poly(disulfide)s with tunable side chains. A novel monomer bearing thiolactone and pyridyl disulfide groups reacts with various amines, enabling continuous ring‐opening and disulfide exchange.
Yukiya Kitayama, Ryodai Sakamoto, Atsushi Harada   +2 more
wiley   +2 more sources

Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance

Lipids in Health and Disease, 2011
Obese subjects with impaired glucose tolerance (IGT) are more susceptible than healthy individuals to oxidative stress and cardiovascular disease.
McNeilly Andrea M, Davison Gareth W, Murphy Marie H, Nadeem Nida, Trinick Tom, Duly Ellie, Novials Anna, McEneny Jane   +7 more
doaj   +1 more source

Protective Effects of α-lipoic acid on Biological changes Induced by α- cypermethrin in Testis Rats [PDF]

Journal of Bioscience and Applied Research, 2018
a-cypermethrin is one of the most potent insecticides used worldwide. This study was planned to evaluate the possible role of a-lipoic acid in a-cypermethrin induced toxicity in rats.
A. Sedky, A. Ali
doaj   +1 more source

In Vivo Anti-inflammatory Activity of Lipoic Acid Derivatives in Mice  [PDF]

, 2013
Background: In mammals lipoic acid (LA) and its reduced form dihydrolipoic acid (DHLA) function as cofactors for multienzymatic complexes catalyzing the decarboxylation of α-ketoacids.
Anna Bilska-Wilkosz, Brunon Kwiecień, Inga Kwiecień, Jacek Sapa, Joanna Knutelska, Lidia Włodek, Magdalena Dudek, Marek Bednarski, Maria Sokołowska-Jeżewicz, Małgorzata Iciek, Małgorzata Zygmunt   +10 more
core   +1 more source

Synergistic Effect of Quercetin and α-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats

Journal of Toxicology, 2018
Objectives. The present study was carried out to study the protective effects of quercetin and α-lipoic acid alone and in combination against aluminum chloride induced neurotoxicity in rats. Materials and Methods.
Sooad Saud Al-Otaibi, Maha Mohamad Arafah, Bechan Sharma, Abdullah Salih Alhomida, Nikhat Jamal Siddiqi   +4 more
doaj   +1 more source

α-lipoic acid ameliorates hepatotoxicity induced by chronic ammonia toxicity in crucian carp (Carassius auratus gibelio) by alleviating oxidative stress, inflammation and inhibiting ERS pathway

Ecotoxicology and Environmental Safety, 2023
High environment ammonia (HEA) poses a deadly threat to aquatic animals and indirectly impacts human healthy life, while nutritional regulation can alleviate chronic ammonia toxicity. α-lipoic acid exhibits antioxidative effects in both aqueous and lipid
Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li   +6 more
doaj   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source