Results 41 to 50 of about 21,573 (205)

α-Lipoic acid exerts a primary prevention for the cardiac dysfunction in aortocaval fistula-created rat hearts

Heliyon, 2019
Aim: α-Lipoic acid exerts a powerful antioxidant effect by acting as a free radical scavenger and inducing endogenous antioxidants such as vitamin E and glutathione. In the present study, we examined the effects of α-lipoic acid on cardiac dysfunction in
Daisuke Kurumazuka, Kento Kitada, Ryosuke Tanaka, Tatsuhiko Mori, Mamoru Ohkita, Masanori Takaoka, Yasuo Matsumura   +6 more
doaj   +1 more source

Dihydrolipoic acid reduces cytochrome b561 proteins. [PDF]

, 2013
Cytochrome b561 (Cyt-b561) proteins constitute a family of trans-membrane proteins that are present in a wide variety of organisms. Two of their characteristic properties are the reducibility by ascorbate (ASC) and the presence of two distinct b-type ...
A Bast, A Bérczi, A Bérczi, A Bérczi, A Bérczi, A Bérczi, A Glanfield, A Mizutani, AA Herbert, Alajos Bérczi, AT McKie, AV Kozlov, C Sgherri, D Griesen, D Han, D Zhang, E Okuyama, ELR Stokstad, ER Henry, F Desmet, GE Tusnády, GE Tusnády, GP Biewenga, GP Biewenga, H Asard, H Kataoka, H Scholich, Han Asard, J Lykkesfeldt, JCH Shih, JS Oakhill, L Cenacchi, L Packer, L Packer, L Packer, L Zimányi, LJ Reed, László Zimányi, M Lakshminarasimhan, M Srivastava, M Tsubaki, M Tsubaki, MAK Markwell, MC Recuenco, O Terland, PJ Fleming, PM Kelley, R Yasuno, RI Shrager, S Ludwiczek, SJ Booker, T Flatmark, TW Nichols, U Pérez-López, UM Kent, V Preger, VE Kagan, W Liu, W Liu, W Verelst, Y Li, Y Nanasato   +61 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

α-Lipoic acid as the main pharmacological drug for in- and outpatient treatment of diabetic polyneuropathy

Медицинский совет, 2016
α-Lipoic acid (thioctic) (ALA) is the most applicable pharmacological drug for treatment of diabetic polyneuropathy. The articles explores the results of experimental studies on α-Lipoic acid effect upon formation mechanisms of peripheral nerves ...
I. A. Strokov, A. S. Phokina
doaj   +1 more source

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]

, 2020
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core   +1 more source

Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial [PDF]

, 2013
Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes. The aim of this study was to evaluate the inositol and alpha lipoic acid combination effectiveness on ...
Botti, Gerardo, Brillante, Giuseppe, Capasso, Immacolata, Cavalcanti, Ernesta, CILIBERTO, GENNARO, CRISPO, ANNA, D'Aiuto, Giuseppe, D'Aiuto, Massimiliano, DE LAURENTIIS, MICHELINO, ESPOSITO, EMANUELA, Esposito, Giuseppe, Frasci, Giuseppe, Fucito, Alfredo, Grimaldi, Maria, Maurea, Nicola, Montella, Maurizio   +15 more
core   +1 more source

Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings

Advanced Materials, EarlyView.
Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed, Yu‐Hsuan Peng, Azra Atabay, Krishna Gupta, Toni Müller, Carolin Fischer, Ilka M. Hermes, Jens‐Uwe Sommer, Michael Lang, Elisha Krieg   +9 more
wiley   +1 more source

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

Effect of UV Irradiation on Interactions of α-Lipoic Acid with Free Radicals

International Journal of Photoenergy, 2013
Changes of antioxidant properties of α-lipoic acid (LA) after UV irradiation were studied. LA is the typical drug used in diabetic neuropathy. Quenching of free radicals is an important factor of therapy by using this substance.
Paweł Ramos, Piotr Pepliński, Barbara Pilawa   +2 more
doaj   +1 more source

Oral plus vaginal alpha-lipoic acid in women at risk for preterm delivery [PDF]

, 2018
Objective: The etiology of preterm labor is multifactorial. An inflammatory response is always involved with the activation of NF-kB that determines synthesis and release of inflammatory molecules, implicated in fetal membrane activation, cervical ...
Giallombardo V., Guardino M., Mocera G., Venezia R, Vitrano G.   +4 more
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