Results 61 to 70 of about 1,093,472 (256)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Antibody-free targeted proteomics assay for absolute measurement of α-tubulin acetylation

, 2020
Acetylation of α-tubulin at conserved lysine 40 (K40) amino acid residue regulates microtubule dynamics and controls a wide range of cellular activities.
Wali, Gautam, Shah, Alok K., Sue, Carolyn M., Hill, Michelle M., Mackay-Sim, Alan, Shah, Alok K, Hill, Michelle M, Sue, Carolyn M   +7 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

MOESM3 of A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin

, 2019
Additional file 3: Figure S3. Localization of different spindle pole proteins in 3,4,4′-TMS treated cells. HCT116 cells were exposed to 40 μM 3,4,4′-TMS and then immunostained with anti-Aurora A and anti-α-tubulin antibodies, anti-TPX2 and anti-α-tubulin
Zulema Percario (6574118), Francesca Degrassi (231524), Daniela Trisciuoglio (132747), Renata Cozzi (651264), Gianandrea Traversi (6574112), David Staid (6574115), Veronica Morea (1495819), Mario Fiore (231517), Roberto Antonioletti (201575)   +8 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

MOESM5 of A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin

, 2019
Additional file 5: Figure S5. Comparison of colchicine binding to γ/γ- and α/β-tubulin dimer. β- and γ-tubulin are shown as ribbon and coloured dark green and cyan, respectively.
Zulema Percario (6574118), Francesca Degrassi (231524), Daniela Trisciuoglio (132747), Renata Cozzi (651264), Gianandrea Traversi (6574112), David Staid (6574115), Veronica Morea (1495819), Mario Fiore (231517), Roberto Antonioletti (201575)   +8 more
core   +1 more source

Cryo-EM structures of the tubulin cofactors reveal the molecular basis of alpha/beta-tubulin biogenesis

Nature Communications
Microtubule polarity and dynamic polymerization arise from the self-association properties of the αβ-tubulin heterodimer. For decades, it has remained unclear how the tubulin cofactors TBCD, TBCE, TBCC, and the Arl2 GTPase mediate the biogenesis of αβ ...
Aryan Taheri, Zhoaqian Wang, Bharti Singal, Fei Guo, Jawdat Al-Bassam   +4 more
doaj   +1 more source

Novel α-Tubulin Mutations Conferring Resistance to Dinitroaniline Herbicides in Lolium rigidum

Frontiers in Plant Science, 2018
The dinitroaniline herbicides (particularly trifluralin) have been globally used in many crops for selective grass weed control. Consequently, trifluralin resistance has been documented in several important crop weed species and has recently reached a ...
Zhizhan Chu, Zhizhan Chu, Jinyi Chen, Alex Nyporko, Heping Han, Qin Yu, Stephen Powles   +6 more
doaj   +1 more source

Differential modification of the C-terminal tails of different α-tubulins and their importance for microtubule function in vivo

eLife, 2023
Microtubules (MTs) are built from α-/β-tubulin dimers and used as tracks by kinesin and dynein motors to transport a variety of cargos, such as mRNAs, proteins, and organelles, within the cell.
Mengjing Bao, Ruth E Dörig, Paula Maria Vazquez-Pianzola, Dirk Beuchle, Beat Suter   +4 more
doaj   +1 more source