Results 51 to 60 of about 902,322 (261)

Additional file 2: of A detection of benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene in Haemonchus contortus from wild blue sheep (Pseudois nayaur) sympatric with sheep in Helan Mountains, China

, 2019
Table S2. Information on 36 different isotype-1 β-tubulin gene haplotypes from eight H. contortus groups in China. (DOC 14 kb)
Shen, Dong-dong, Peng, Zhi-wei, Hu, Min, Zhang, Zong-ze, Hou, Zhi-jun, Liu, Zhen-sheng   +5 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Correlation of serum anti-tubulin-α-1cantibodies with clinical features of RA patients.

, 2018
Correlation of serum anti-tubulin-α-1cantibodies with clinical features of RA patients.
Cibo Huang (444680), Lei Zhu (16642), Xiaolin Sun (53844), Yuling Chen (438010), Yuhui Li (478816), Haiteng Deng (138991), Zhanguo Li (28423), Yongjing Cheng (444681), Rulin Jia (446574), Xiaozhen Zhao (4579963)   +9 more
core   +1 more source

α-Tubulin acetylation on lysine 40 controls cardiac glucose uptake.

, 2022
Our group previously demonstrated that an excess of nutrients, as observed in diabetes, provokes an increase in cardiac protein acetylation responsible for a reduced insulin-stimulated translocation of the glucose transporter GLUT4 to the plasma membrane.
Fourny, Natacha, Renguet, Edith, Bouzin, Caroline, De Loof, Marine, Bultot, Laurent, Horman, Sandrine, Bertrand, Luc, Ginion, Audrey, Poüs, Christian, Beauloye, Christophe   +9 more
core   +1 more source

Additional file 1: of A detection of benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene in Haemonchus contortus from wild blue sheep (Pseudois nayaur) sympatric with sheep in Helan Mountains, China

, 2019
Table S1. Information on 24 different isotype-1 β-tubulin gene haplotypes from two H. contortus groups isolated form sympatric blue sheep and sheep. (DOC 13 kb)
Shen, Dong-dong, Peng, Zhi-wei, Hu, Min, Zhang, Zong-ze, Hou, Zhi-jun, Liu, Zhen-sheng   +5 more
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The performance of anti-tubulin-α-1c antibodies and anti-endothelial cell antibodies in BD diagnosis.

, 2018
The performance of anti-tubulin-α-1c antibodies and anti-endothelial cell antibodies in BD diagnosis.
Cibo Huang (444680), Lei Zhu (16642), Xiaolin Sun (53844), Yuling Chen (438010), Yuhui Li (478816), Haiteng Deng (138991), Zhanguo Li (28423), Yongjing Cheng (444681), Rulin Jia (446574), Xiaozhen Zhao (4579963)   +9 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Antibody-free targeted proteomics assay for absolute measurement of α-tubulin acetylation

, 2020
Acetylation of α-tubulin at conserved lysine 40 (K40) amino acid residue regulates microtubule dynamics and controls a wide range of cellular activities.
Wali, Gautam, Shah, Alok K., Sue, Carolyn M., Hill, Michelle M., Mackay-Sim, Alan, Shah, Alok K, Hill, Michelle M, Sue, Carolyn M   +7 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source