Characterisation of the benzimidazole-binding site on the cytoskeletal protein tubulin [PDF]
, 2003 The binding kinetics of several benzimidazole compounds were determined with recombinant tubulin monomers and heterodimers from benzimidazole-sensitive and -insensitive organisms.
MacDonald, Louisa M.
core
Correlation of serum anti-tubulin-α-1cantibodies with clinical features of RA patients.
, 2018 Correlation of serum anti-tubulin-α-1cantibodies with clinical features of RA patients.
Cibo Huang (444680) +9 more
core +1 more source
Balancing Act: Tubulin Glutamylation and Microtubule Dynamics in Toxoplasma gondii
MicroorganismsThe success of the intracellular parasite Toxoplasma gondii in invading host cells relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The T. gondii genome encodes three isoforms of both α-
Inês L. S. Delgado +7 more
doaj +1 more source
In silico prediction of three-dimensional structure and interactome analysis of Tubulin α subfamily of Arabidopsis thaliana [PDF]
Network Biology, 2014 Microtubules are essential components of cytoskeleton, rigid hollow rods approximately 25 nm in diameter. Microtubules are dynamic structures being continuously assembled and disassembled within the cell.
Jasmin Sutkovic +1 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Phenotype difference of BD patients who are anti-tubulin-α-1c positive and negative.
, 2018 Phenotype difference of BD patients who are anti-tubulin-α-1c positive and negative.
Cibo Huang (444680) +9 more
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Prevalence of anti-tubulin-α-1c in BD patients and controls.
, 2018 Prevalence of anti-tubulin-α-1c in BD patients and controls.
Cibo Huang (444680) +9 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2018 The performance of anti-tubulin-α-1c antibodies and anti-endothelial cell antibodies in BD diagnosis.
Cibo Huang (444680) +9 more
core +1 more source