Results 71 to 80 of about 1,093,472 (256)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
, 2013 Western blots for tubulin (pan-Tub) and acetyl-α-tubulin (Ac-Tub) in brain extracts of WT and KO mice, both female and male (A, B). Genotypes are indicated at the top of each lane and sex at the bottom.
Zhenxia Qin (311680) +4 more
core +1 more source
Фактори експериментальної еволюції організмів, 2019 Aim. To evaluate polymorphism of dinitroaniline/phosphorothioamidate binding site in α-tubulin molecules from Plasmodium species (P. falciparum, P. vivax, P. ovale, and P. malariae) and strains discovered in India. Methods.
P. A. Karpov +5 more
doaj +1 more source
Tubulin expression and modification in heart failure with preserved ejection fraction (HFpEF)
Scientific Reports, 2022 Diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) is characterised by increased left ventricular stiffness and impaired active relaxation. Underpinning pathomechanisms are incompletely understood. Cardiac hypertrophy and end
Lisa Schulz +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Tubulin fehérje fragmens és pontmutánsának kölcsönhatása átmenetifém-ionokkal
, 2023 Diplomamunkámban a tubulin α doménjének természetes fragmensét (Tub α 1A (195-203)) tanulmányoztam átmenetifém-ionokkal. Ezen fehérjerészlet ciszteint és hisztidint is egyaránt tartalmaz, ezenfelül az -SXC- motívum is fellelhető benne. Célul tűztük ki az
Szondi, Fruzsina Kíra
core
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Фактори експериментальної еволюції організмів, 2019 Aim. Computational prediction of amino acid residues critical for specific binding of nitro- and dinitroaniline compounds in plant α-tubulin. Methods.
S. P. Ozheredov +4 more
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Impact of the non-acetylatable α-tubulin expression.
, 2022 HeLa cells were co-transfected with plasmids encoding BHRF1-HA (or EV) and mCherry-α-tubulin K40A (or WT). (A) Immunoblot analysis of acetyl-α-tubulin, α-tubulin and HA. (B) Confocal images of EVtransfected cells immunostained for TOM20.
Audrey Esclatine (8067290) +10 more
core +1 more source