Results 91 to 100 of about 1,007,835 (176)

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Effects of α-Tubulin K40 Acetylation and Detyrosination on Kinesin-1 Motility in a Purified System [PDF]

, 2014
Long-range transport in cells is achieved primarily through motor-based transport along a network of microtubule tracks. Targeted transport by kinesin motors can be correlated with posttranslational modifications (PTMs) of the tubulin subunits in ...
Soppina, Virupakshi, Verhey, Kristen J., Kaul, Neha   +2 more
core   +1 more source

(+)-Naloxone inhibits morphine-induced chemotaxis via prevention of heat shock protein 90 cleavage in microglia

Journal of the Formosan Medical Association, 2015
Microglia have a crucial role in maintaining neuronal homeostasis in the central nervous system. Immune factors released from microglia have important roles in nociceptive signal transduction.
Ru-Yin Tsai, Yu-Che Cheng, Chih-Shung Wong   +2 more
doaj   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

α-tubulin acetylation and detyrosination correlate with starvation-induced autophagy in tobacco cells

, 2017
Recent data has enabled discovery of novel functions of microtubules (MTs) in the regulation of autophagy development under physiologic/stressful conditions in yeast and animal cells.
Yaroslav B. Blume, Dmytro I. Lytvyn, Alla I. Yemets   +2 more
core   +1 more source

HDAC6 decreases H4K16 and α-tubulin acetylation during porcine oocyte maturation. [PDF]

Cell Cycle, 2023
Zhang S, Sui L, Kong X, Huang R, Li Z.
europepmc   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Knockdown of Mdp3 expression reduces the level of tubulin acetylation.

, 2014
(A) HeLa cells were transfected with control or Mdp3 siRNAs. The levels of Mdp3, acetylated α-tubulin, and α-tubulin were then examined by immunoblotting with antibodies against Mdp3, acetylated α-tubulin, and α-tubulin. (B) Experiments were performed as
Tala (285182), Dengwen Li (285184), Linlin Zhang (131810), Xiaoou Sun (532931), Min Liu (45756), Jie Chen (5892), Jun Zhou (6477), Ningning Liu (292952)   +7 more
core   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

, 2011
Dynamic instability is a critical property of microtubules (MTs). By regulating the rate of tubulin polymerization and depolymerization, cells organize the MT cytoskeleton to accommodate their specific functions.
Donald S. Kirkpatrick, Hui Zou, Fajian Hou, Lilian Phu, Yingming Zhao, Chih-Wen Chu, Alex V. Loktev, Junmei Zhang, Peter K. Jackson   +8 more
core   +1 more source