Results 71 to 80 of about 1,007,835 (176)

Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila

Disease Models & Mechanisms, 2017
Tau normally associates with and stabilizes microtubules (MTs), but is hyperphosphorylated and aggregated into neurofibrillary tangles in Alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies.
Chuan-Xi Mao, Xue Wen, Shan Jin, Yong Q. Zhang   +3 more
doaj   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Synaptic branch stability is mediated by non-enzymatic functions of MEC-17/αTAT1 and ATAT-2

Scientific Reports, 2022
Microtubules are fundamental elements of neuronal structure and function. They are dynamic structures formed from protofilament chains of α- and β-tubulin heterodimers.
Jean-Sébastien Teoh, Amruta Vasudevan, Wenyue Wang, Samiksha Dhananjay, Gursimran Chandhok, Roger Pocock, Sandhya P. Koushika, Brent Neumann   +7 more
doaj   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

HSV-1 infection facilitates α-tubulin acetylation which is inhibited by Hsp90 inhibition.

, 2014
(A) Western blotting shows HSV-1 infection enhanced acetylation of α-tubulin. (B) Colocalization between Hsp90 and acetylated α-tubulin is reduced by Hsp90 inhibition.
Kai Zheng (558943), Fujun Jin (558942), Tao Peng (81319), Yifei Wang (95207), Kaiqi Ma (558945), Kaio Kitazato (514972), Xianxiu Qiu (573190), Meigong Zhong (573188), Qiaoli Wang (558947), Yangfei Xiang (573189), Maoyun Chen (558946)   +10 more
core   +1 more source

Analysis of the role of acetylation in Giardia lamblia and the giardicidal potential of garcinol

Frontiers in Microbiology
IntroductionPost-translational modifications of proteins provide cellular physiology with a broad range of adaptability to the external environment flexibly and rapidly.
Rocío G. Patolsky, Jerónimo Laiolo, Jerónimo Laiolo, Luciano Díaz-Pérez, Gabriel Luna Pizarro, Gonzalo F. Mayol, María C. Touz, Constanza Feliziani, Andrea S. Rópolo   +8 more
doaj   +1 more source

Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice

The Journal of Reproduction and Development, 2020
The structure of microtubules is essential for the fertilizing ability of spermatozoa. Acetylation of α-tubulin plays an important role in flagellar elongation and spermatozoa motility.
Rin YANAI, Yudai YAMASHITA, Kohei UMEZU, Yuuki HIRADATE, Kenshiro HARA, Kentaro TANEMURA   +5 more
doaj   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes. [PDF]

, 2010
BACKGROUND: Antimalarial interventions designed to impact on the transmissible sexual stages of Plasmodium falciparum are evaluated by measurement of peripheral gametocyte carriage in vivo and infectivity to mosquitoes.
Sutherland, Colin J, Drakeley, Chris J, Drakeley Chris J., Samana Schwank, Schwank, Samana, Chris J. Drakeley, Colin J Sutherland, Sutherland Colin J., Schwank Samana, Colin J. Sutherland, Chris J Drakeley   +10 more
core   +2 more sources

Linking acetylated α-Tubulin redistribution to α-Synuclein pathology in brain of Parkinson’s disease patients

npj Parkinson's Disease
Highly specialized microtubules in neurons are crucial to both health and disease of the nervous system, and their properties are strictly regulated by different post-translational modifications, including α-Tubulin acetylation.
Samanta Mazzetti, Federica Giampietro, Alessandra Maria Calogero, Huseyin Berkcan Isilgan, Gloria Gagliardi, Chiara Rolando, Francesca Cantele, Miriam Ascagni, Manuela Bramerio, Giorgio Giaccone, Ioannis Ugo Isaias, Gianni Pezzoli, Graziella Cappelletti   +12 more
doaj   +1 more source