Results 121 to 130 of about 1,007,835 (176)
An LCK/PPARG/SCD Lipid Metabolism Axis Promotes Invasion in Human Oral Cancer
MedComm, Volume 7, Issue 10, October 2026.Oral squamous cell carcinoma (OSCC) progression is driven by invasive tumor‐cell phenotypes, for which effective targeted therapies remain limited. Here, we identify a tumor‐cell‐intrinsic LCK/PPARG/SCD axis, in which LCK regulates PPARG expression and H3K27 acetylation, while PPARG promotes lipid remodeling and SCD‐dependent fatty acid desaturation to
Jonas Pyko +8 more
wiley +1 more source
Copper Catalyzed sp3 C-H α-Acetylation
, 2019 α-substituted ketones are important chemical targets as synthetic intermediates as well as functionalities in in natural products and pharmaceuticals.
Thomas Cundari (8154571) +4 more
core +1 more source
Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging
Aging Cell, Volume 25, Issue 10, October 2026.We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang +12 more
wiley +1 more source
Anti-tubulin-α-1cantibody levels in patients and healthy controls.
, 2018 The sensitivity and specificity of tubulin-α-1c antibody in the diagnosis of BD were 61.36% and 88.4% respectively. (BD 44, SLE 51, RAU 32, HC 59, AASV 25, TA 13).
Cibo Huang (444680) +9 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 20, Page 6199-6224, October 2026.Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang +11 more
wiley +1 more source
MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of α-tubulin acetylation. [PDF]
Cell Prolif, 2020 Wang X +11 more
europepmc +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, Volume 293, Issue 19, Page 5717-5734, October 2026.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 10, Page 5320-5339, October 2026.ABSTRACT Microtubules (MTs) are crucial for cell division, growth, development and morphogenesis in plants. Cotton fibres are single‐celled trichomes that originate from the epidermal cells of the ovule, making them an excellent model for studying plant cell differentiation and rapid elongation.
Xiaowei Ma +18 more
wiley +1 more source
Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity
Plant, Cell &Environment, Volume 49, Issue 10, Page 7604-7618, October 2026.ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette +5 more
wiley +1 more source
HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation. [PDF]
Cell Cycle, 2020 Sui L, Zhang S, Huang R, Li Z.
europepmc +1 more source