Results 131 to 140 of about 1,078,681 (181)

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Acetylation of α-tubulin K40 is dispensable for viability, microtubule assembly and stability but supports cellular robustness in Trypanosoma brucei

Microtubules of eukaryotic cells are regulated at multiple levels, including the expression of distinct tubulin isotypes, interactions with regulatory proteins, and a wide range of post-translational modifications (PTMs).
Klaus Ersfeld, Stephanie Lamer, Matthias Weiss, Hannes Wunderlich, Andreas Schlosser, Lucas Brehm   +5 more
core   +1 more source

An LCK/PPARG/SCD Lipid Metabolism Axis Promotes Invasion in Human Oral Cancer

MedComm, Volume 7, Issue 10, October 2026.
Oral squamous cell carcinoma (OSCC) progression is driven by invasive tumor‐cell phenotypes, for which effective targeted therapies remain limited. Here, we identify a tumor‐cell‐intrinsic LCK/PPARG/SCD axis, in which LCK regulates PPARG expression and H3K27 acetylation, while PPARG promotes lipid remodeling and SCD‐dependent fatty acid desaturation to
Jonas Pyko, Tamara Tomin, Markus Glaß, Lisa Müller, Jana Macho, Matthias Schittmayer, Monika Haemmerle, Ruth Birner‐Gruenberger, Tony Gutschner   +8 more
wiley   +1 more source

The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation. [PDF]

J Biol Chem, 2020
Tan HF, Tan SM.
europepmc   +1 more source

Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging

Aging Cell, Volume 25, Issue 10, October 2026.
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang, Yue Wang, Caizhu Wang, Xin Guo, Huanhua Chen, Yu‐Xuan Hou, Xuan Wu, Zi‐Jian Wu, Wen‐Lin Pan, Rui‐Jie Ma, Ping‐Shuang Lu, Jinhui Shu, Shao‐Chen Sun   +12 more
wiley   +1 more source

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6199-6224, October 2026.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/α-tubulin acetylation. [PDF]

Autophagy, 2020
Ouyang C, Mu J, Lu Q, Li J, Zhu H, Wang Q, Zou MH, Xie Z.   +7 more
europepmc   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, Volume 293, Issue 19, Page 5717-5734, October 2026.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

GhTTLL12 Coordinates With Transcriptional Regulators GhMML3 and GhMYB86 to Orchestrate Cotton Fibre Development Through Modulating Microtubule Dynamics

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5320-5339, October 2026.
ABSTRACT Microtubules (MTs) are crucial for cell division, growth, development and morphogenesis in plants. Cotton fibres are single‐celled trichomes that originate from the epidermal cells of the ovule, making them an excellent model for studying plant cell differentiation and rapid elongation.
Xiaowei Ma, Xubinmiao Huang, Jinfang Li, Ting Zhao, Zhenfeng Ling, Shengcai Huang, Zesheng Rui, Yue Shi, Yulin Xing, Lei Sun, Mengting Wang, Haoxi Song, Rui Chen, Zequan Chen, Lei Shao, Nangan Sun, Junduo Wang, Juyun Zheng, Lei Fang   +18 more
wiley   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, Volume 49, Issue 10, Page 7604-7618, October 2026.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source