Results 91 to 100 of about 1,585,908 (347)

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

Aging Cell, 2019
Renal fibrosis is the common pathological feature in a variety of chronic kidney diseases. Aging is highly associated with the progression of renal fibrosis. Among several determinants, mitochondrial dysfunction plays an important role in aging. However,
Jin-hua Miao, Jiafeng Liu, Jing Niu, Yunfang Zhang, Weiwei Shen, C. Luo, Yahong Liu, Chuanjiang Li, Hongyan Li, P. Yang, Youhua Liu, F. Hou, Lili Zhou   +12 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma

Molecular Cancer, 2008
Aberrant Wnt-signaling caused by mutants of β-catenin, a key regulator of the canonical Wnt-signaling pathway, is frequently detected in cancer. Only recently, it was suggested that in hepatocellular carcinoma (HCC) the expression of the target gene ...
Gebhardt Rolf, Tannapfel Andrea, Wittekind Christian, Dunsch Ruediger, Austinat Madeleine, Gaunitz Frank   +5 more
doaj   +1 more source

Retraction statement: MicroRNA‐222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β‐catenin signaling pathway [PDF]

, 2021
Qifeng Li, Ke Shen, Yang Zhao, Xiaoguang He, Chenkai Ma, Lin Wang   +5 more
openalex   +1 more source

MOESM1 of LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells

, 2019
Additional file 1: Figure S1.Overview image of immunofluorescence staining (GFAP+) in SCI animal models at 1 and 2 weeks post-injury were shown.
Cui, Yi, Yin, Yanyun, Xiao, Zhifeng, Zhao, Yannan, Chen, Bing, Yang, Bin, Xu, Bai, Song, Hongwei, Zou, Yunlong, Ma, Xu, Dai, Jianwu   +10 more
openaire   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane

Journal of Skin Cancer, 2014
We have previously demonstrated that Rad6 and β-catenin enhance each other's expression through a positive feedback loop to promote breast cancer development/progression. While β-catenin has been implicated in melanoma pathogenesis, Rad6 function has not
Karli Rosner, Darius R. Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P. V. Shekhar   +9 more
doaj   +1 more source

iNOS activation regulates β-catenin association with its partners in endothelial cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Signals that disrupt β-catenin association to cadherins may influence the translocation of β-catenin to the nucleus to regulate transcription.
Deyarina Gonzalez, Armando Rojas, Maria Beatriz Herrera, R Steven Conlan   +3 more
doaj   +1 more source

Additional file 8: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

, 2019
Table S1. Clinicopathological characteristics of 102 HCC patients. (DOC 38 kb)
Deng, Ling, Jingyuan Sun, Xiaohui Chen, Liu, Li, Dehua Wu   +4 more
openaire   +1 more source

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

Molecular Brain, 2019
Alzheimer’s disease (AD) is an aging-related neurological disorder characterized by synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellular processes including cell survival.
Lin Jia, J. Piña-Crespo, Yonghe Li
semanticscholar   +1 more source