Results 11 to 20 of about 1,585,908 (347)
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Signal Transduction and Targeted Therapy, 2022 The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer
Jiaqi Liu +8 more
semanticscholar +1 more source
Study of β-Catenin as Immunohistochemistry Marker in Women with Breast Cancer
Iraqi Journal of Science, 2021 Background & Objective: Breast cancer (BC) is the most prevalent disease among women around the world, considered the world's leading cause of death (15% of the total cancer deaths) in women in 2018. β-catenin is a multifunctional protein located in the cytoplasm and/or nucleus of the cell.
Ruqayah Ali Salman +2 more
openaire +2 more sources
Discovery of novel small molecule activators of β-catenin signaling. [PDF]
PLoS ONE, 2011 Wnt/β-catenin signaling plays a major role in embryonic development and adult stem cell maintenance. Reduced activation of the Wnt/β-catenin pathway underlies neurodegenerative disorders and aberrations in bone formation.
Folkert Verkaar +4 more
doaj +1 more source
Frontiers in Oncology, 2022 Casein kinase 1δ/ϵ (CK1δ/ϵ) are well-established positive modulators of the Wnt/β-catenin signaling pathway. However, the molecular mechanisms involved in the regulation of β-catenin transcriptional activity by CK1δ/ϵ remain unclear.
Jiong Ning +13 more
doaj +1 more source
β-Catenin expression is associated with cell invasiveness in pancreatic cancer [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. Methods We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line.
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
doaj +1 more source
Wnt/β-catenin signaling in cancers and targeted therapies
Signal Transduction and Targeted Therapy, 2021 Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression ...
F. Yu +8 more
semanticscholar +1 more source
β-Catenin signaling in hepatocellular carcinoma
Journal of Clinical Investigation, 2022 Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular carcinoma (HCC). Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which encodes β-catenin, and loss-of-function ...
Chuanrui Xu +5 more
semanticscholar +1 more source
Emerging Direct Targeting β-Catenin Agents
Molecules, 2022 Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin ...
Marianna Nalli +4 more
doaj +1 more source
LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
Haematologica, 2019 Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients ...
Rhys G. Morgan +12 more
doaj +1 more source
Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis. [PDF]
PLoS ONE, 2016 β-catenin signaling is a major oncogenic pathway in hepatocellular carcinoma (HCC). Since β-catenin phosphorylation by glycogen synthase kinase 3β (GSK3β) and casein kinase 1ε (CK1ε) results in its degradation, mutations affecting these phosphorylation ...
Hirohisa Okabe +15 more
doaj +1 more source