Results 21 to 30 of about 1,585,908 (347)

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice

BMC Cancer, 2018
Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcinogenesis.
Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga, Diego F Calvisi, Xin Chen   +7 more
doaj   +1 more source

Targeting the Wnt/β-catenin signaling pathway in cancer

Journal of Hematology & Oncology, 2020
The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response.
Ya Zhang, Xin Wang
semanticscholar   +1 more source

90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus

Neoplasia: An International Journal for Oncology Research, 2016
β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation.
So-Yeon Park, Somy Yoon, Hangun Kim, Kyung Keun Kim   +3 more
doaj   +1 more source

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer

Journal of Translational Medicine, 2023
Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.
Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang   +8 more
doaj   +1 more source

Phase separation of Axin organizes the β-catenin destruction complex

Journal of Cell Biology, 2021
Assembly of the destruction complex is critical for Wnt/β-catenin signaling. Nong et al. find that Axin undergoes liquid–liquid phase separation, which is promoted by APC.
Junxiu Nong, Kexin Kang, Qiaoni Shi, Xuechen Zhu, Qinghua Tao, Ye-Guang Chen   +5 more
semanticscholar   +1 more source

β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB

Cancer Cell International, 2020
Background Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood.
Shu-Guang Liu, Zhi-Xia Yue, Zhi-Gang Li, Rui-Dong Zhang, Hu-Yong Zheng, Xiao-Xi Zhao, Chao Gao   +6 more
doaj   +1 more source

Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. [PDF]

PLoS ONE, 2010
The APC tumour suppressor functions in several cellular processes including the regulation of β-catenin in Wnt signalling and in cell adhesion and migration.In this study, we establish that in epithelial cells N-terminally phosphorylated β-catenin ...
Maree C Faux, Janine L Coates, Nadia J Kershaw, Meredith J Layton, Antony W Burgess   +4 more
doaj   +1 more source

Direct targeting of β‐catenin in the Wnt signaling pathway: Current progress and perspectives

Medicinal research reviews (Print), 2021
Aberrant activation of the Wnt/β‐catenin signaling circuit is associated with cancer recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion.
Zhen Wang, Zilu Li, Haitao Ji
semanticscholar   +1 more source

Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway

BMC Veterinary Research, 2020
Background Bovine parainfluenza virus type 3 (BPIV3) is one of the important viral respiratory agents associated with the bovine respiratory disease complex (BRDC) in cattle.
Xinying Du, Wenqi He, Hongbin He, Hongmei Wang   +3 more
doaj   +1 more source

The epithelial-mesenchymal transition induced by transcription factor LEF-1 is independent of β-catenin

Biochemistry and Biophysics Reports, 2018
Transcription factor lymphoid-enhancer–binding factor 1 (LEF-1) is a key molecule in the Wnt/β-catenin signaling pathway. Slug is one of the Wnt/β-catenin target genes and can induce epithelial–mesenchymal transition (EMT). Previously, we have shown that
Wakako Kobayashi, Masayuki Ozawa
doaj   +1 more source