Results 31 to 40 of about 1,585,908 (347)
Journal of Hepatocellular Carcinoma, 2021 Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is considered as the most common primary liver cancer. HCC remains a challenging disease to treat.
Mahshid Deldar Abad Paskeh +4 more
semanticscholar +1 more source
Amyloid precursor protein modulates β-catenin degradation
Journal of Neuroinflammation, 2007 Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
doaj +1 more source
Stem Cell Reports, 2016 Summary: Treatment with several Wnt/β-catenin signaling pathway regulators can change the cellular reprogramming efficiency; however, the dynamics and role of endogenous Wnt/β-catenin signaling in reprogramming remain largely unanswered. Here we identify
Mizuki Kimura +3 more
doaj +1 more source
Potential Canonical Wnt Pathway Activation in High-Grade Astrocytomas
The Scientific World Journal, 2012 Aberrant wnt pathway activation through cytoplasmic stabilization of β-catenin is crucial for the development of various human malignancies. In gliomagenesis, the role of canonical (i.e., β-catenin-dependent) signalling is largely unknown.
Rebecca Schüle +11 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2013 β-Catenin is important in liver homeostasis as a part of Wnt signaling and adherens junctions (AJs), while its aberrant activation is observed in hepatocellular carcinoma (HCC).
Emily Diane Wickline +4 more
doaj +1 more source
Cell Death and Disease, 2023 Hepatocellular carcinoma (HCC) is the most common type of primary hepatic carcinoma, which is a growing public health problem worldwide. One of the main genetic alterations in HCC is the deregulated Wnt/β-catenin signaling, activation of β-catenin is ...
Jianing Tang +3 more
doaj +1 more source
Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin
Cell Reports, 2015 Some cancer cells exhibit elevated levels of free fatty acids (FAs) as well as high levels of β-catenin, a transcriptional co-activator that promotes their growth. Here, we link these two phenomena by showing that unsaturated FAs inhibit degradation of β-
Hyeonwoo Kim +7 more
doaj +1 more source
Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma cells. [PDF]
PLoS ONE, 2011 Metastatic melanoma is a leading cause of death from skin diseases, and is often associated with activation of Wnt/β-catenin signaling pathway. We have examined the inhibitory effect of silymarin, a plant flavanoid from Silybum marianum, on cell ...
Mudit Vaid +3 more
doaj +1 more source
Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation. [PDF]
PLoS ONE, 2013 β-catenin, an adherens junction component and key Wnt pathway effector, regulates numerous developmental processes and supports embryonic stem cell (ESC) pluripotency in specific contexts.
Sujeivan Mahendram +6 more
doaj +1 more source
, 2020 Additional file 7: Table S1. The siRNA sequences of GLP-1R and TCF-4.
Feng, Yun +7 more
openaire +1 more source