Results 41 to 50 of about 1,585,908 (347)

A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition. [PDF]

PLoS ONE, 2011
The Wnt/β-catenin signalling pathway shares a key component, β-catenin, with the cadherin-based adhesion system. The signalling function of β-catenin is conferred by a soluble cytoplasmic pool that is unstable in the absence of a Wnt signal, whilst the ...
Sara Howard, Tom Deroo, Yasuyuki Fujita, Nobue Itasaki   +3 more
doaj   +1 more source

MOESM8 of Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway

, 2020
Additional file 8: Table S2. The qRT-PCR sequences of primers.
Feng, Yun, Linlin Wang, Xiaoying Ma, Xiaotong Yang, Ocholi Don, Xiaoyan Chen, Jieming Qu, Yuanlin Song   +7 more
openaire   +1 more source

Aberrant nuclear localization of β-catenin without genetic alterations in β-catenin or Axin genes in esophageal cancer

World Journal of Surgical Oncology, 2007
Background β-catenin is a multifunctional protein involved in two apparently independent processes: cell-cell adhesion and signal transduction. β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation.
Shinoda Noriyuki, Sugiura Hironori, Terashita Yukio, Shibata Yasuyuki, Ishiguro Hideyuki, Haruki Nobuhiro, Nishiwaki Tadashi, Kudo Junzo, Kimura Masahiro, Kuwabara Yoshiyuki, Fujii Yoshitaka   +10 more
doaj   +1 more source

HOXC10 Protects from Skin Aging by Targeting the FZD6/Wnt/β-Catenin Signaling Pathway. [PDF]

Research (Wash D C)
Zhong Y, Guo Y, Mao R, Zhou L, Wang F, Meng X, Xiao X, Yuan H, Zhang Y, Deng Z, Shi W, Wang Q, Xie H, Zhang Y, Li J.   +14 more
europepmc   +2 more sources

WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers

Clinical Cancer Research, 2019
Purpose: The T-cell-inflamed phenotype correlates with efficacy of immune-checkpoint blockade, whereas non-T-cell-inflamed tumors infrequently benefit.
J. Luke, R. Bao, R. Sweis, S. Spranger, T. Gajewski   +4 more
semanticscholar   +1 more source

β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma.

Cancer Discovery, 2019
PD-1 immune checkpoint inhibitors have produced encouraging results in hepatocellular carcinoma (HCC) patients. However, what determines resistance to anti-PD-1 therapies is unclear.
M. Ruiz de Galarreta, Erin R. Bresnahan, Pedro Molina-Sánchez, K. Lindblad, B. Maier, D. Sia, M. Puigvehí, Verónica Miguela, M. Casanova-Acebes, Maxime Dhainaut, C. Villacorta-Martin, A. Singhi, A. Moghe, J. von Felden, Lauren Tal Grinspan, Shuang Wang, A. Kamphorst, S. Monga, Brian D. Brown, A. Villanueva, J. Llovet, M. Merad, A. Lujambio   +22 more
semanticscholar   +1 more source

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.

PLoS Biology, 2020
Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly studied. However, how the maternal β-catenin activity is suppressed in the nondorsal cells remains poorly understood.
Mudan He, Ru Zhang, Shengbo Jiao, Fenghua Zhang, Ding Ye, Houpeng Wang, Yonghua Sun   +6 more
doaj   +1 more source

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

International Journal of Molecular Sciences, 2020
Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular ...
B. Choi
semanticscholar   +1 more source

Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish

Biology Open, 2019
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin and ...
Sharanya M. Kalasekar, Srishti Kotiyal, Christopher Conley, Cindy Phan, Annika Young, Kimberley J. Evason   +5 more
doaj   +1 more source

Stabilisation of β-catenin downstream of T cell receptor signalling. [PDF]

PLoS ONE, 2010
The role of TCF/β-catenin signalling in T cell development is well established, but important roles in mature T cells have only recently come to light.Here we have investigated the signalling pathways that are involved in the regulation of β-catenin in ...
Matthew Lovatt, Marie-José Bijlmakers
doaj   +1 more source