Results 51 to 60 of about 1,585,908 (347)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Scientific Reports, 2023 Unrestrained transcriptional activity of β-CATENIN and its binding partner TCF7L2 frequently underlies colorectal tumor initiation and is considered an obligatory oncogenic driver throughout intestinal carcinogenesis.
Janna Fröhlich +2 more
doaj +1 more source
The role of β-catenin in tooth development
AL-QADISIYAH MEDICAL JOURNAL, 2017 Background:The present experimental study was conducted on tooth development during embryogenesis in developing mouse. with main objective to identify the expression and action β -Catenin in development of teeth and mophogenesis. Materials and Methods:This study comprised a total of (21) sections were selected during different stages of tooth ...
openaire +1 more source
, 2018 Figure S1. Upregulation of Wnt signaling leads to proliferation of human ES cell-derived cardiomyocytes. Figure S2. Expression levels of Wnt signaling genes are affected in a cardiac hypertrophy model. Table S1. Lists of human and murine primer sequences used in this study. (DOCX 167 kb)
Fan, Yong +6 more
openaire +1 more source
, 2023 <p>PKCÎ'-silenced PC3 (a) and LNCaP (b) cells were treated with DMSO or paclitaxel 2.5 µM 48 hours. Histograms show densitometric and statistical analysis of indicated proteins from panels (c) and (d) of the Figure 3. Data are presented as mean{plus minus}S.E.M.
Carmen Sáez +7 more
openaire +1 more source
The regulation of β-catenin activity and function in cancer: therapeutic opportunities
OncoTarget, 2017 Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known to be involved in embryonic development, tissue homeostasis and a wide variety of human diseases.
Shuang Shang, Fang Hua, Zhuo-wei Hu
semanticscholar +1 more source
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer
Cells, 2020 The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases and cancers, especially as a key driver in the initiation and progression of ...
Jia Bian +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease. [PDF]
PLoS ONE, 2011 Chronic obstructive pulmonary disease (COPD) is characterized by abnormal extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has been associated with abnormal ECM turnover in various chronic diseases. We determined WNT-
Hoeke A Baarsma +9 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source