Results 61 to 70 of about 1,585,908 (347)

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling. [PDF]

PLoS ONE, 2017
Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) pathology. We searched for a pre-approved drug that suppresses abnormally activated Wnt/β-catenin signaling and has a potency to reduce joint pathology in OA.
Kentaro Miyamoto, Bisei Ohkawara, Mikako Ito, Akio Masuda, Akihiro Hirakawa, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Naoki Ishiguro, Kinji Ohno   +9 more
doaj   +1 more source

Additional file 1: of Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation

, 2019
Table S1. Mouse oligonucleotide primers used for real time RT-PCR. Table S2. Human oligonucleotide primers used for real time RT-PCR. (DOC 34 kb)
Lee, Dong, Park, Mi, Hwang, Chul, Youngsoo Kim, Hwang, Dae, Han, Sang, Hong, Jin   +6 more
openaire   +1 more source

Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

Journal of Hematology & Oncology
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation.
Pan Song, Zirui Gao, Yige Bao, Li Chen, Yuhe Huang, Yanyan Liu, Qiang Dong, Xiawei Wei   +7 more
semanticscholar   +1 more source

β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

Journal of Experimental Medicine, 2020
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Our findings reveal an important mechanism of PD-L1 up-regulation elicited by AKT-dependent β-catenin activation and highlight the clinical significance of β-catenin activation ...
Linyong Du, Jong-Ho Lee, Hongfei Jiang, Chengde Wang, Silu Wang, Zhihong Zheng, Fei Shao, Daqian Xu, Yan Xia, Jing Li, Yanhua Zheng, Xu Qian, Xinjian Li, Hyung-Ryong Kim, Dongming Xing, Pengyuan Liu, Zhimin Lu, J. Lyu   +17 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis

eLife, 2016
Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Blair W Benham-Pyle, Joo Yong Sim, Kevin C Hart, Beth L Pruitt, William James Nelson   +4 more
doaj   +1 more source

Wnt/β-catenin-driven EMT regulation in human cancers

Cellular and Molecular Life Sciences
Metastasis accounts for 90% of cancer-related deaths among the patients. The transformation of epithelial cells into mesenchymal cells with molecular alterations can occur during epithelial–mesenchymal transition (EMT).
Wenhua Xue, Lin Yang, Chengxin Chen, M. Ashrafizadeh, Yu Tian, R. Sun   +5 more
semanticscholar   +1 more source

The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling

Molecular Cancer, 2017
BackgroundWith more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in the development of CRC.MethodsWe examined
Peng Han, Jing-wen Li, Bo-miao Zhang, Jiachen Lv, Yong-min Li, Xin-yue Gu, Zhiwei Yu, Yun-he Jia, Xuefeng Bai, Li Li, Yan-Long Liu, Binbin Cui   +11 more
semanticscholar   +1 more source

Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway

Journal of experimental & clinical cancer research : CR, 2021
Background Cancer stem cell (CSC)-related chemoresistance leads to poor outcome of the patients with colorectal cancer (CRC). In this study, we identified the chemoresistance-relevant molecules and decipher the involved mechanisms to provide potential ...
Xiaofeng Liu, Kun Su, Xiaoyan Sun, Yangsen Jiang, Li-Jun Wang, Chenyu Hu, Chun-feng Zhang, Min Lu, Xiaojuan Du, B. Xing   +9 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source