Results 71 to 80 of about 1,585,908 (347)

Elevated levels of Dickkopf-1 are associated with β-catenin accumulation and poor prognosis in patients with chondrosarcoma. [PDF]

PLoS ONE, 2014
BACKGROUND: Dickkopf-1 (DKK1) is an antagonist of Wnt/β-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and β-catenin involved in chondrosarcoma has not been sufficiently investigated.
Changbao Chen, Hua Zhou, Xiaolin Zhang, Xinlong Ma, Zhongjun Liu, Xiaoguang Liu   +5 more
doaj   +1 more source

Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury

Frontiers in Cell and Developmental Biology, 2021
Objective: Activation of β-catenin causes podocyte injury and proteinuria, but how β-catenin signalling is regulated during podocyte injury remains elusive.
Qing Hou, Qing Hou, Weibo Le, Shuyan Kan, Jinsong Shi, Yue Lang, Zhihong Liu, Zhihong Liu, Zhaohong Chen, Zhaohong Chen   +9 more
doaj   +1 more source

Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

PLoS Biology, 2006
The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation.
Amanda J Mikels, R. Nusse
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

MOESM1 of Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

, 2019
Additional file 1: Table S1. Primers used for RT-qPCR.
Fengjun Xuan, Yano, Fumiko, Mori, Daisuke, Chijimatsu, Ryota, Maenohara, Yuji, Nakamoto, Hideki, Mori, Yoshifumi, Makii, Yuma, Oichi, Takeshi, Taketo, Makoto, Hojo, Hironori, Ohba, Shinsuke, Ung-Il Chung, Tanaka, Sakae, Saito, Taku   +14 more
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Additional file 4: of Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

, 2019
Table S3. The sequences of primers used in plasmid construction. (DOCX 14 kb)
Li, Yun, Yan, Xiaoli, Shi, Jiajian, He, Yun, Xu, Jie, Lin, Liying, Chen, Wannan, Lin, Xinjian, Lin, Xu   +8 more
openaire   +1 more source

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

Science Advances, 2020
Targeting β-catenin–dependent gene regulation in macrophages may offer a new immunotherapeutic option in lung cancer. Tumor-associated macrophages (TAMs) influence lung tumor development by inducing immunosuppression.
Poonam Sarode, Xiang Zheng, Georgia A. Giotopoulou, A. Weigert, C. Kuenne, S. Günther, Aleksandra Friedrich, S. Gattenlöhner, T. Stiewe, B. Brüne, F. Grimminger, G. Stathopoulos, S. Pullamsetti, W. Seeger, R. Savai   +14 more
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Additional file 3: of Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

, 2019
Table S2. Clinicopathological characteristics of studied patients and expression of miR-188-5p in STAD from the FMU Cohort. (DOCX 15 kb)
Li, Yun, Yan, Xiaoli, Shi, Jiajian, He, Yun, Xu, Jie, Lin, Liying, Chen, Wannan, Lin, Xinjian, Lin, Xu   +8 more
openaire   +1 more source