Results 81 to 90 of about 1,585,908 (347)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Additional file 5: of Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

, 2019
Table S4. The sequences of primers used in real-time RT-PCR assay. (DOCX 14 kb)
Li, Yun, Yan, Xiaoli, Shi, Jiajian, He, Yun, Xu, Jie, Lin, Liying, Chen, Wannan, Lin, Xinjian, Lin, Xu   +8 more
openaire   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

15,16-Dihydrotanshinone I, a novel β-catenin-targeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer

Journal of Translational Medicine
Background Wnt/β-catenin signaling drives many cancers; however, current inhibition strategies have limitations. Direct β-catenin inhibitors that block nuclear translocation represent an alternative therapeutic approach.
Minting Chen, Baisen Chen, Qianyi He, Shilin Xiao, Baoting Li, Yun Ye, Hongjie Zhang, Hoi Leong Xavier Wong, Ying Ji, Tao Su, Hiu Yee Kwan   +10 more
doaj   +1 more source

Astragalus Inhibits Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells by Down-Regulating β-Catenin

Cellular Physiology and Biochemistry, 2018
Background/Aims: The epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is a crucial event in the induction of peritoneal fibrosis (PF), in which canonical Wnt/β-catenin signaling participates.
Manshu Yu, Jun Shi, Meixiao Sheng, Kun Gao, Lu Zhang, Li Liu, Yilin Zhu   +6 more
doaj   +1 more source

Additional file 1: of Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma

, 2018
Supplementary experiments and routine methods. Figure S1. Spheroid formation capability of HCC cell lines. Figure S2. β-catenin expression in HepG2 cell line. Figure S3. Knockdown efficiency of siRNA transfection. Routine Methods: Immunocytochemistry (ICC) Staining, Flow-Cytometry Analysis, Protein Extraction and Western Blot. Table S1.
Pandit, Harshul, Li, Yan, Li, Xuanyi, Zhang, Weizhong, Li, Suping, Martin, Robert   +5 more
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

β-Catenin Controls the Electrophysiologic Properties of Skeletal Muscle Cells by Regulating the α2 Isoform of Na+/K+-ATPase

Frontiers in Neuroscience, 2019
β-Catenin is a key component of the canonical Wnt signaling pathway. It has been shown to have an important role in formation of the neuromuscular junction. Our previous studies showed that in the absence of β-catenin, the resting membrane potential (RMP)
Congying Zhao, Yonglin Yu, Yi Zhang, Jue Shen, Lihua Jiang, Guoxia Sheng, Weiqin Zhang, Lu Xu, Kewen Jiang, Kewen Jiang, Kewen Jiang, Shanshan Mao, Shanshan Mao, Peifang Jiang, Feng Gao   +14 more
doaj   +1 more source

Additional file 2: of Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

, 2019
Table S1. Clinicopathological characteristics of studied patients and expression of miR-188-5p in STAD from TCGA Dataset. (DOCX 16 kb)
Li, Yun, Yan, Xiaoli, Shi, Jiajian, He, Yun, Xu, Jie, Lin, Liying, Chen, Wannan, Lin, Xinjian, Lin, Xu   +8 more
openaire   +1 more source