Results 141 to 150 of about 2,747,637 (331)

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

β-Galactosidase

, 2015
Das Ziel dieser Masterarbeit war die Reinigung und Charakterisierung einer β-Galaktosidase aus der spanischen Wegschnecke (Arion lusitanicus). Die β-Galaktosidase, die zur Familie der Exoglykosidasen zählt, spaltet β-glykosidische Bindungen zwischen ...
Korb, Elke
core   +1 more source

Optimization and partial purification of beta-galactosidase production by Aspergillus niger isolated from Brazilian soils using soybean residue

AMB Express, 2019
β-Galactosidases are widely used for industrial applications. These enzymes could be used in reactions of lactose hydrolysis and transgalactosylation. The objective of this study was the production, purification, and characterization of an extracellular ...
Raquel Dall’Agnol Martarello, Luana Cunha, Samuel Leite Cardoso, Marcela Medeiros de Freitas, Damaris Silveira, Yris Maria Fonseca-Bazzo, Mauricio Homem-de-Mello, Edivaldo Ximenes Ferreira Filho, Pérola Oliveira Magalhães   +8 more
doaj   +1 more source

Image_7_Activated microglia release β−galactosidase that promotes inflammatory neurodegeneration.tif

Beta (β)-galactosidase is a lysosomal enzyme that removes terminal galactose residues from glycolipids and glycoproteins. It is upregulated in, and used as a marker for, senescent cells.
Guy C. Brown (7848366), Jacob M. Dundee (17777562), Emily J. A. Kitchener (12433398)   +2 more
core   +1 more source

Tracing Gene Expression Through Detection of β-galactosidase Activity in Whole Mouse Embryos

, 2018
The Escherichia coli LacZ gene, encoding β-galactosidase, is largely used as a reporter for gene expression and as a tracer in cell lineage studies. The classical histochemical reaction is based on the hydrolysis of the substrate X-gal in combination ...
Rodríguez Martín, Iván, Muñoz Sáez, Emma, Blanco, María José, Blanco Fernández de Valderrama, María José, Sánchez-Camacho Blázquez, Cristina, Rodríguez-Martín, Iván, Marchena, Miguel Ángel, Rodríguez Learte, Ana Isabel, Marchena, Miguel, Muñoz-Sáez, Emma, Cid, María Antonia, Cid Torres, María Antonia, Learte, Ana   +12 more
core   +1 more source

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source

Sequential Design of Activatable Photosensitizers for Ablation of Glioma Cells in Brain Cancer Tissues

Angewandte Chemie, EarlyView.
Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar, Zhiming Cheng, Andrew D. M. Green, Sam Benson, Eleni Nestoros, Clarissa Lim, Justyna Cholewa‐Waclaw, Fabio de Moliner, Paula Lusarreta, Deborah Seah, Alsadeg Bilal, Neza Alfazema, Thibaud Aymoz‐Bressot, Gillian Morrison, Sonja Vermeren, Steven M. Pollard, Paul M. Brennan, Michael G. Tanner, Marc Vendrell   +18 more
wiley   +2 more sources

CreA-mediated carbon catabolite repression of β-galactosidase formation inAspergillus nidulansis growth rate dependent [PDF]

FEMS Microbiology Letters, 2004
Hedvig Ilyés, Erzsébet Fekete, Levente Karaffa, Éva Fekete, Erzsébet Sándor, Attila Szentirmai, Christian P. Kubicek   +6 more
openaire   +1 more source

Image_6_Activated microglia release β−galactosidase that promotes inflammatory neurodegeneration.TIFF

Beta (β)-galactosidase is a lysosomal enzyme that removes terminal galactose residues from glycolipids and glycoproteins. It is upregulated in, and used as a marker for, senescent cells.
Guy C. Brown (7848366), Jacob M. Dundee (17777562), Emily J. A. Kitchener (12433398)   +2 more
core   +1 more source

Β-Galactosidase-Catalyzed Fluorescent Reporter Labeling of Living Cells for Sensitive Detection of Cell Surface Antigens

, 2020
The ability to detect cell surface proteins using fluorescent dye-labeled antibodies is crucial for the reliable identification of many cell types. However, the different types of cell surface proteins used to identify cells are currently limited in ...
Munetaka Ishiyama (8347217), Masanobu Shiga (8347220), Takeshi Mori (7471958), Yoshiki Katayama (7471961), Yuichiro Ueno (8347223), Katsuya Noguchi (8342919), Takashi Shimomura (8347211), Yuya Ohuchi (8347214)   +7 more
core   +1 more source