Results 181 to 190 of about 2,747,637 (331)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Bacterial Species Associated With Chronic Inflammation and Oral Cancer. A Comparative Study Between Patients With HNC and Patients With Chronic Periodontitis

Cancer Nexus, EarlyView.
ABSTRACT Objective To compare the presence and quantification of selected periodontopathogenic bacterial species and salivary parameters between patients with head and neck cancer (HNC) treated with radiotherapy and patients with chronic periodontitis, using chronic periodontitis as a reference model of oral dysbiosis.
Tanya Pereira‐Riveros, José López‐López, Alicia Lozano‐Borbalas, Julio Paciello‐Coronel, Teresa Vinuesa   +4 more
wiley   +1 more source

Systematic assessment of Pichia pastoris system for optimized β -galactosidase production

Synthetic and Systems Biotechnology, 2017
Hongbing Sun, Olufemi Emmanuel Bankefa, Ijeoma Onyinyechi Ijeoma, Liangtian Miao, Taicheng Zhu, Yin Li   +5 more
doaj   +1 more source

Purification and Some Properties of β-Mannosidase, β-N-Acetylglucosaminidase, and β-Galactosidase from Apple Snails (Pomacea canaliculata)

, 1998
β -Mannosidase, β -N-acetylglucosaminidase, and β -galactosidase were purified from the viscera of apple snails (Pomacea canaliculata) using ammonium sulfate precipitation, hydrophobic chromatography on Butyl Toyopearl 650M, gel filtration on Sephacryl S-
Aso, Yoichi, Hirata, Koji, 平田, 考治, Ishiguro, Masatsune, 石黒, 正恒, 麻生, 陽一   +5 more
core  

Fluorinated Iminosugar Glycomimetics: Synthesis and Activity as GCase Ligands

European Journal of Organic Chemistry, EarlyView.
DAST‐mediated deoxyfluorination of suitably functionalized piperidines provided regio‐ and stereoselective access to fluorinated piperidine and pyrrolidine glycomimetics, the latter arising from an unusual ring‐contraction process. Fluorination generally enhanced β‐glucocerebrosidase (GCase) inhibitory potency, but lost PC activity toward L444P/L444P ...
Francesca Mangiavacchi, Alessio Morano, Cosimo Margheri, Cristina Faggi, Amelia Morrone, Camilla Matassini, Francesca Clemente, Andrea Goti, Martina Cacciarini, Francesca Cardona   +9 more
wiley   +1 more source

From Enrichment to Insight: Leveraging Preparative cIEF Enrichments and Characterization to Support Data‐Driven Integration Practices for cIEF‐based Analytics

ELECTROPHORESIS, EarlyView.
Preparative cIEF enrichment enabled isolation of a low‐abundance, poorly resolved basic charge variant identified during routine cIEF analysis. Orthogonal characterization by peptide mapping and SCX‐UV–MS revealed incomplete N‐terminal pyroglutamate formation and Fc methionine oxidation.
Ramya Rao, Dominik Herrmann, Seamus Kelley, Victoria Cotham, Logan Figular, Youmi Moon, Deanna Di Grandi, Kathir Muthusamy, Yue Fu, Nisha Palackal, Shunhai Wang, Ning Li, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles   +14 more
wiley   +1 more source

Body‐integrated photonic biosensors: Illuminating the path to active healthcare

FlexMat, EarlyView.
Body‐integrated photonic biosensors are promising tools for active healthcare. These optical devices can be worn, implanted, or swallowed to monitor health signals continuously. This review introduces key sensing modalities, including fluorescence, colorimetry, SPR, LSPR, SERS, and light‐modulating materials.
Jiayue Gu, Xingming Wen, Qihang Yan, Yining Zhao, Linghao Yuan, Siyuan Chen, Yue Ma, Zhengyue Fang, Dong Lei, Yuxin Liu, Ze Xiong   +10 more
wiley   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Rhenium-Based β-Galactosidase Probe Allows Senescence Profiling by Mass Cytometry. [PDF]

Angew Chem Int Ed Engl
Tam A, Elbein K, Gonzalez AG, Arriaga EA, Nitz M.   +4 more
europepmc   +1 more source