Results 11 to 20 of about 144,498 (294)

The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics [PDF]

Antibiotics
Background: Therapeutic strategies for methicillin-resistant Staphylococcus aureus (MRSA) are increasingly limited due to the ability of the pathogen to evade conventional treatments such as vancomycin and daptomycin. This challenge has shifted the focus
Nader Abdelmalek, Sally Waheed Yousief, Martin Saxtorph Bojer, Mosaed Saleh A. Alobaidallah, John Elmerdahl Olsen, Bianca Paglietti   +5 more
doaj   +2 more sources

Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.

JAMA
Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock. Objective To determine whether prolonged β-lactam antibiotic infusions
Abdul-Aziz MH, Hammond NE, Brett SJ, Cotta MO, De Waele JJ, Devaux A, Di Tanna GL, Dulhunty JM, Elkady H, Eriksson L, Hasan MS, Khan AB, Lipman J, Liu X, Monti G, Myburgh J, Novy E, Omar S, Rajbhandari D, Roger C, Sjövall F, Zaghi I, Zangrillo A, Delaney A, Roberts JA.   +24 more
europepmc   +2 more sources

Machine learning models for coagulation dysfunction risk in inpatients administered β-lactam antibiotics [PDF]

Frontiers in Pharmacology
The β-Lactam antibiotics represent a widely used class of antibiotics, yet the latent and often overlooked risk of coagulation dysfunction associated with their use underscores the need for proactive assessment.
Yuqing Hua, Yuqing Hua, Na Li, Jiahui Lao, Zhaoyang Chen, Shiyu Ma, Xiao Li   +6 more
doaj   +2 more sources

β-lactam antibiotics induce metabolic perturbations linked to ROS generation leads to bacterial impairment [PDF]

Frontiers in Microbiology
Understanding the impact of antibiotics on bacterial metabolism is crucial for elucidating their mechanisms of action and developing more effective therapeutic strategies.
Dongyang Ye, Dongyang Ye, Dongyang Ye, Jing Sun, Jing Sun, Ran Jiang, Jiashen Chang, Yiming Liu, Xiangzheng Wu, Luqi Li, Yihan Luo, Juan Wang, Juan Wang, Juan Wang, Kangkang Guo, Kangkang Guo, Kangkang Guo, Zengqi Yang, Zengqi Yang, Zengqi Yang   +19 more
doaj   +2 more sources

Mutations in ampD cause hyperproduction of AmpC and CmcB β-lactamases and high resistance to β-lactam antibiotics in Chromobacterium violaceum [PDF]

Microbiology Spectrum
Bacterial resistance to β-lactam antibiotics mediated by β-lactamase enzymes is widespread worldwide. Chromobacterium violaceum, an environmental Gram-negative bacterial pathogen, is intrinsically resistant to some β-lactam antibiotics.
Luís Gustavo Laranjeiro, Carlos Eduardo M. Neme, Maristela Previato-Mello, Bianca B. Batista, Isabel Henriques, José F. da Silva Neto   +5 more
doaj   +2 more sources

β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward

Frontiers in Microbiology, 2023
β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar, Medha Chakraborty, Shashi Kumari, Deepjyoti Paul, Bhabatosh Das   +4 more
doaj   +1 more source

Giant linear plasmids of β-lactam antibiotic producing Streptomyces [PDF]

FEMS Microbiology Letters, 1995
A survey of the total cellular DNA from five β-lactam antibiotic-producing Streptomyces spp. by pulsed field gel electrophoresis was conducted to investigate the presence of linear plasmids. Streptomyces clavuligerus NRRL 3585 contained two giant linear plasmids of 120 and 430 kb, in addition to the well-characterized 11.7 kb linear plasmid ...
Donald J. Netolitzky, Xiaoning Wu, Susan E. Jensen, Kenneth L. Roy   +3 more
openaire   +1 more source

Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus

Antibiotics, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality.
Harshad Lade, Hwang-Soo Joo, Jae-Seok Kim   +2 more
semanticscholar   +1 more source

A method to transform the β-lactam antibiotic producerStreptomyces wadayamensis [PDF]

FEMS Microbiology Letters, 1986
We have developed a transformation system for Streptomyces wadayamensis, a cephamycin C producer. 1−5 × 109 protoplasts can be obtained when late logarithmic phase cultures of this microorganisms are incubated with 10 mg/ml of lysozyme. Polyethylene glycol-Ca2+-mediated transformation of these protoplasts yielded 106 transformants per μg of pIJ702 or ...
C. Acebal, V. Rubio, G. Márquez
openaire   +1 more source

β-Lactam Antibiotics and β-Lactamase Enzymes Inhibitors, Part 2: Our Limited Resources

Pharmaceuticals, 2022
β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the increasing emergence of resistance to them, developed by bacteria producing β-lactamase enzymes (BLEs), is becoming one of the major warnings to the global public health.
S. Alfei, A. Schito
semanticscholar   +1 more source