Results 121 to 130 of about 86,850 (260)

Investigation of the sheltering effect of β-lactam-resistant K.pneumoniae species on twosusceptible E. coli and S. aureus strains

, 2023
There is increasing evidence that microbial interactions can happen within microbial communities resulting in an increase of the pathogen resistance to antimicrobial therapies.
Silvia Caprari (7520882)
core   +1 more source

Cefdinir reprograms Gram‐positive bacteria to synergize with lysozyme against superbugs

mLife, EarlyView.
Abstract Multidrug‐resistant (MDR) bacteria pose a critical global health threat, urgently requiring solutions. Cefdinir, the highest‐selling third‐generation cephalosporin but one now facing clinical obsolescence due to escalating resistance, is conventionally classified as a nascent cell wall synthesis inhibitor.
Qi Zhang, Yang Yang, Shuqi Li, Zhao Liu, Chun‐Kit Lee, Chi‐Bun Ko, Qian Zhao   +6 more
wiley   +1 more source

The road to avibactam: The first clinically useful non-β-lactam working somewhat like a β-lactam

, 2016
Avibactam, which is the first non-β-lactam β-lactamase inhibitor to be introduced for clinical use, is a broad-spectrum serine β-lactamase inhibitor with activity against class A, class C, and, some, class D β-lactamases.
Wang, David Y., Abboud, Martine I., Schofield, Christopher J., Markoulides, Marios S., Brem, Jürgen   +4 more
core   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source

The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

Antibiotics
Background: Therapeutic strategies for methicillin-resistant Staphylococcus aureus (MRSA) are increasingly limited due to the ability of the pathogen to evade conventional treatments such as vancomycin and daptomycin. This challenge has shifted the focus
Nader Abdelmalek, Sally Waheed Yousief, Martin Saxtorph Bojer, Mosaed Saleh A. Alobaidallah, John Elmerdahl Olsen, Bianca Paglietti   +5 more
doaj   +1 more source

β-lactamase of Mycobacterium fortuitum: Kinetics of production and relationship with resistance to β-lactam antibiotics

, 1991
The kinetics of both intracellular and extracellular β-lactamase production and the relationship between extracellular enzyme and in vitro susceptibility of Mycobacterium fortuitum to beta-lactam antibiotics have been studied. To this end we used a panel
Shao Hong Jin, Null, AMICOSANTE, Gianfranco, FRANCESCHINI, Nicola, Fattorini, L, Scardaci, G., ORATORE, Arduino, Orefici, G.   +6 more
core   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source

Combination Antibacterial Therapy against β-lactam Drug Resistance

, 2016
University of Minnesota Ph.D. dissertation.June 2016. Major: Biomedical Informatics and Computational Biology. Advisors: Yuk Sham, Claudia Neuhauser.
Shin, Woo Shik
core  

Respiratory infections, bacterial resistance and therapy with β-lactam antibiotics

, 2011
β-lactam antibiotics are the largest antibiotic group, so bacterial resistance against them has a pivotal role in the antibacterial therapy. there are four mechanisms for beta-lactam resistance from which two: the changes in penicillin-binding proteins ...
Yankov, K.; Marina university
core   +1 more source

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source