Results 141 to 150 of about 74,609 (245)

Analysis of two Nocardia brasiliensis class A β-lactamases (BRA-1 and BRS-1) and related resistance to β-lactam antibiotics

Journal of Global Antimicrobial Resistance
: Objective: Molecular determinants of β-lactam resistance are poorly explored for most Nocardia species, such as Nocardia brasiliensis. In this study, we characterised resistance mediated by two β-lactamases in the reference strain N.
Aimee Songo, Hervé Jacquier, Maxime Danjean, Fabrice Compain, Delphine Dorchène, Zainab Edoo, Paul-Louis Woerther, Michel Arthur, David Lebeaux   +8 more
doaj   +1 more source

Clinical guideline highlights for the hospitalist: Recommendations for pneumonia in hospitalized children with neurologic impairment

Journal of Hospital Medicine, EarlyView.
Elizabeth L. Nichols, J. Andrew Watson
wiley   +1 more source

Cefepime Combined with Late-Generation β-Lactamase Inhibitors: Mechanisms of Action, In Vitro Activity, PK/PD Characteristics, Clinical Evidence and Resistance Mechanisms

Antibiotics
Cefepime combined with late-generation β-lactamase inhibitors—enmetazobactam, zidebactam, and taniborbactam—represents a promising strategy to treat multidrug-resistant Gram-negative infections.
Sara Comini, Matteo Boattini, Paolo Gaibani, Gabriele Bianco   +3 more
doaj   +1 more source

Adaptive β-lactam resistance from an inducible efflux pump that is post-translationally regulated by the DjlA co-chaperone. [PDF]

PLoS Biol, 2023
Costafrolaz J, Panis G, Casu B, Ardissone S, Degeorges L, Pilhofer M, Viollier PH.   +6 more
europepmc   +1 more source

Constitutional symptoms and response to Penicillin G in erysipelas and cellulitis – a monocentric, retrospective, explorative study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background: Erysipelas, caused by streptococci, should be treated with penicillin, while uncomplicated cellulitis (phlegmon), often caused by Staphylococcus aureus, requires penicillinase‐resistant beta‐lactam antibiotics, which have a higher risk of adverse effects. Distinguishing between these infections is important.
Helena Schieffers, Cord Sunderkötter
wiley   +1 more source

Multidrug resistance of bacterial pathogens in canine pyometra

Journal of Small Animal Practice, EarlyView.
Objectives To characterise multidrug antimicrobial resistance and pathogenicity profiles of bacteria isolated from different anatomical sites in bitches with pyometra, emphasising their clinical relevance for diagnosis and therapeutic decision‐making in small animal practice.
M. G. M. Camozzi, S. B. Waller, E. C. Castelhano, A. L. S. Neves, B. R. Arrais, J. F. N. Pinto, B. G. Alves, C. N. Moreira   +7 more
wiley   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Proposed Meropenem Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Bacteria Isolated From Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Meropenem is a carbapenem antibiotic used infrequently in veterinary medicine. However, antimicrobial susceptibility testing standards are needed to monitor for resistance caused by carbapenem resistant Enterobacterales (CRE). The Clinical and Laboratory Standards Institute (CLSI) does not have veterinary‐specific carbapenem breakpoints for ...
Mark G. Papich, Marilyn N. Martinez
wiley   +1 more source

Trapping and Characterization of a Reaction Intermediate in Carbapenem Hydrolysis by \u3cem\u3eB. cereus\u3c/em\u3e Metallo-β-lactamase [PDF]

, 2008
Metallo-β-lactamases hydrolyze most β-lactam antibiotics. The lack of a successful inhibitor for them is related to the previous failure to characterize a reaction intermediate with a clinically useful substrate.
Tioni, Mariana F., Llarrull, Leticia l., Poeylaut-Palena, Andrés A., Martí, Marcelo A., Saggu, Miguel, Periyannan, Gopal R., Mata, Ernesto G., Bennett, Brian, Murgida, Daniel H., Vila, Alejandro J.   +9 more
core   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Molecular Microbiology, EarlyView.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang, Charlène Cornilleau, Lena Friebel, Sarah Spitzner, Raphael R. Müller, Doreen Meier, Pierre Flores, Cyprien Guérin, Pierre Nicolas, Diana Wolf, Vincent Fromion, Rut Carballido‐López, Thorsten Mascher   +12 more
wiley   +1 more source