Results 151 to 160 of about 45,473 (217)

Understanding and addressing β-lactam resistance mechanisms in gram-negative bacteria in Lebanon: A scoping review. [PDF]

Heliyon
Khachab Y, Hodroj M, Salem Sokhn E.
europepmc   +1 more source

Morphological change of coiled bacterium Spirosoma linguale with acquisition of β-lactam resistance. [PDF]

Sci Rep, 2021
Maeda T, Kotani H, Furusawa C.
europepmc   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari, Sepideh Elyasi, Farshad Abedi   +2 more
wiley   +1 more source

An antisense peptide-conjugated peptide nucleic acid (PPNA) for peptidoglycan recycling inhibition reduces AmpC hyperproduction and β-lactam resistance in <i>Pseudomonas aeruginosa</i>. [PDF]

Microbiol Spectr
Escobar-Salom M, Barceló IM, Sansó-Sastre J, Torrens G, Jordana-Lluch E, Moyà B, Oliver A, Juan C.   +7 more
europepmc   +1 more source

Prevalence of High-Risk β-Lactam Resistance Genes in Family Livestock Farms in Danjiangkou Reservoir Basin, Central China. [PDF]

Int J Environ Res Public Health, 2022
Yang F, Zhang Z, Li Z, Han B, Zhang K, Yang P, Ding Y.   +6 more
europepmc   +1 more source

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 394-398, August 2026.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Structural shifts in TolC facilitate Efflux-Mediated β-lactam resistance. [PDF]

Commun Biol
Kantarcioglu I, Gaszek IK, Guclu TF, Yildiz MS, Atilgan AR, Toprak E, Atilgan C.   +6 more
europepmc   +1 more source

Impact of PBP4 Alterations on β-Lactam Resistance and Ceftobiprole Non-Susceptibility Among Enterococcus faecalis Clinical Isolates. [PDF]

Front Cell Infect Microbiol, 2021
Lazzaro LM, Cassisi M, Stefani S, Campanile F.   +3 more
europepmc   +1 more source

Two Novel 1,4‐Naphthoquinone Derivatives as Potent Agents Against Multidrug‐Resistant Staphylococcus aureus and Pathogenic Gram‐Positive Bacteria

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Drug‐resistant bacteria such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Quinolone‐resistant S. aureus (QRSA), are a growing problem, creating a need for the development of novel antimicrobial agents. In this study, we designed and synthesized two novel 1,4‐naphthoquinone derivatives, LHN‐1034 and LHN‐1035, and evaluated their ...
HyunChan Song, Haena Lee, Ji‐Hyun Yoon, Hyunkyung Choi, Hakwon Kim, Ki‐Young Kim   +5 more
wiley   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, Volume 18, Issue 8, Page 1097-1113, August 2026.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source