Results 171 to 180 of about 86,850 (260)

Nacubactam: a review on mechanistic insights and therapeutic promise for combating β-lactam resistance among multidrug-resistant Gram-negative pathogens. [PDF]

Ann Med Surg (Lond)
Kumar D, Kaur N, Surender, Aman S, Bibi A.   +4 more
europepmc   +1 more source

Mutation of PA4292 in Pseudomonas aeruginosa Increases β-Lactam Resistance through Upregulating Pyocyanin Production. [PDF]

Antimicrob Agents Chemother, 2022
Zhao X, Jin Y, Bai F, Cheng Z, Wu W, Pan X.   +5 more
europepmc   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Peptidoglycan recycling is critical for cell division, cell wall integrity, and β-lactam resistance in <i>Caulobacter crescentus</i>. [PDF]

Elife
Richter P, Merz A, Biboy J, Paczia N, Glatter T, Ng J, Vollmer W, Thanbichler M.   +7 more
europepmc   +1 more source

Tissue and Serum Concentrations of Time‐Dependent Antibiotics in Infected Diabetic Foot Ulcers by Bolus or Continuous Administration: The Randomised DFIATIM Trial

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims The clinical effectiveness of antibiotic (ATB) therapy in patients with infected diabetic foot ulcers (iDFUs) depends on achieving sufficient ATB concentrations in both serum and peripheral tissues. This study evaluated the availability and bactericidal activity of the time‐dependent ATBs—ceftazidime (CTZ) and amoxicillin/clavulanate (AMC)
Radka Jarošíková, Dominika Sojáková, Simona Antalová, Petr Tůma, Jan Polák, Michal Dubský, Andrea Němcová, Veronika Wosková, Pavol Beca, Istvan Modos, Jan Mareš, Jakub Mrázek, Chahrazed Mekadim, Markéta Skružná, Vladimíra Fejfarová   +14 more
wiley   +1 more source

Selection of porin and LPS mutants during infection by phage T4 facilitates the emergence of β-lactam resistance in Escherichia coli. [PDF]

NPJ Antimicrob Resist
Le-Boulch J, Charneau E, Chevallereau A, Gutierrez A.   +3 more
europepmc   +1 more source

Fluorinative Olefin Bond Functionalization of Selected Functionalized Cycloalkenes

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Palladium‐catalyzed ring olefin bond difunctionalization, through functional group and substrate‐dependent arylfluorination, of selected functionalized cycloalkenes has been studied. Palladium‐catalyzed ring olefin bond difunctionalization through arylfluorination of selected five‐, six‐, and seven‐membered functionalized cycloalkenes has been studied.
Tamás T. Novák, Tamás Holczbauer, Máté Sulyok‐Eiler, Pál T. Szabó, Melinda Nonn, Gábor Turczel, Anas Semghouli, Santos Fustero, Jianlin Han, Gábor Hornyánszky, Loránd Kiss   +10 more
wiley   +1 more source

Correction: Staphylococcus aureus in commercial laying hens from Pernambuco, Brazil: detection of efflux pumps and β-lactam resistance genes. [PDF]

Braz J Microbiol
da Silva ÓP, de Sá Barreto Maia Leite DP, da Silva VV, Barbosa IC, Dos Santos SF, Barros MR, Mota RA.   +6 more
europepmc   +1 more source

An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Toward Pan-β-Lactam Resistance. [PDF]

Open Forum Infect Dis, 2023
Simner PJ, Bergman Y, Conzemius R, Jacobs E, Tekle T, Beisken S, Tamma PD.   +6 more
europepmc   +1 more source

The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors

Protein Science, Volume 35, Issue 7, July 2026.
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley   +1 more source